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Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation

Author

Listed:
  • Yang Pan

    (Millennium Pharmaceuticals Inc.)

  • Clare Lloyd

    (Millennium Pharmaceuticals Inc.)

  • Hong Zhou

    (Millennium Pharmaceuticals Inc.)

  • Sylvia Dolich

    (Millennium Pharmaceuticals Inc.)

  • Jim Deeds

    (Millennium Pharmaceuticals Inc.)

  • Jose-Angel Gonzalo

    (Millennium Pharmaceuticals Inc.)

  • Jim Vath

    (Millennium Pharmaceuticals Inc.)

  • Mike Gosselin

    (Millennium Pharmaceuticals Inc.)

  • Jingya Ma

    (Millennium Pharmaceuticals Inc.)

  • Barry Dussault

    (Millennium Pharmaceuticals Inc.)

  • Elizabeth Woolf

    (Millennium Pharmaceuticals Inc.)

  • Geoff Alperin

    (Millennium Pharmaceuticals Inc.)

  • Janice Culpepper

    (Millennium Pharmaceuticals Inc.)

  • Jose Carlos Gutierrez-Ramos

    (Millennium Pharmaceuticals Inc.)

  • David Gearing

    (Millennium Pharmaceuticals Inc.)

Abstract

Chemokines are small secreted proteins that stimulate the directional migration of leukocytes and mediate inflammation1,2,3,4. During screening of a murine choroid plexus complementary DNA library, we identified a new chemokine, designated neurotactin. Unlike other chemokines, neurotactin has a unique cysteine pattern, Cys-X-X-X-Cys, and is predicted to be a type 1 membrane protein. Full-length recombinant neurotactin is localized on the surface of transfected 293 cells. Recombinant neurotactin containing the chemokine domain is chemotactic for neutrophils both in vitro and in vivo. Neurotactin messenger RNA is predominantly expressed in normal murine brain and its protein expression in activated brain microglia is upregulated in mice with experimental autoimmune encephalomyelitis, as well as in mice treated with lipopolysaccharide. Distinct from all other chemokine genes, the neurotactin gene is localized to human chromosome 16q. Consequently we propose that neurotactin represents a new δ-chemokine family and that it may play a role in brain inflammation processes.

Suggested Citation

  • Yang Pan & Clare Lloyd & Hong Zhou & Sylvia Dolich & Jim Deeds & Jose-Angel Gonzalo & Jim Vath & Mike Gosselin & Jingya Ma & Barry Dussault & Elizabeth Woolf & Geoff Alperin & Janice Culpepper & Jose , 1997. "Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation," Nature, Nature, vol. 387(6633), pages 611-617, June.
    • Handle: RePEc:nat:nature:v:387:y:1997:i:6633:d:10.1038_42491
    DOI: 10.1038/42491
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