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The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications

Author

Listed:
  • P. Philippsen

    (Institute for Applied Microbiology, Biozentrum, University of Basel
    Justus-Liebig-Universität Giessen, Institut für Mikro- und Molekularbiologie)

  • K. Kleine

    (Martinsrieder Institut für Protein Sequenzen, Max-Planck-Institut für Biochemie)

  • R. Pöhlmann

    (Institute for Applied Microbiology, Biozentrum, University of Basel)

  • A. Düsterhöft

    (QIAGEN GmbH)

  • K. Hamberg

    (Justus-Liebig-Universität Giessen, Institut für Mikro- und Molekularbiologie)

  • J. H. Hegemann

    (Justus-Liebig-Universität Giessen, Institut für Mikro- und Molekularbiologie)

  • B. Obermaier

    (Laboratorium für Molekulare Biologie, Genzentrum der LMU München
    MediGene GmbH)

  • L. A. Urrestarazu

    (Université Libre de Bruxelles, Physiologie Cellulaire et Génétique des Levures, Boulevard du Triompe CP244)

  • R. Aert

    (Katholieke Universiteit Leuven, Laboratory of Gene Technology)

  • K. Albermann

    (Martinsrieder Institut für Protein Sequenzen, Max-Planck-Institut für Biochemie)

  • R. Altmann

    (Institute for Applied Microbiology, Biozentrum, University of Basel)

  • B. André

    (Université Libre de Bruxelles, Physiologie Cellulaire et Génétique des Levures, Boulevard du Triompe CP244)

  • V. Baladron

    (Universidad de Salamanca)

  • J. P. G. Ballesta

    (Centro de Biologia Molecular, CSIC & UAM, Cantoblanco)

  • A.-M. Bécam

    (Centre de Génétique Moléculaire, Laboratoire propre du CNRS associé à l’Université Pierre et Marie Curie)

  • J. Beinhauer

    (Justus-Liebig-Universität Giessen, Institut für Mikro- und Molekularbiologie)

  • J. Boskovic

    (Centro de Biologia Molecular, CSIC & UAM, Cantoblanco)

  • M. J. Buitrago

    (Universidad de Salamanca)

  • F. Bussereau

    (Université Paris-Sud, Institut de Génétique et Microbiologie, Laboratoire Information Génétique et Développement, Bât. 400)

  • F. Coster

    (Université Catholique de Louvain)

  • M. Crouzet

    (LBMS, Université de Bordeaux 2, UPR CNRS 9026)

  • M. D’Angelo

    (CRIBI Biotechnology Centre, University of Padova)

  • F. Dal Pero

    (CRIBI Biotechnology Centre, University of Padova)

  • A. De Antoni

    (CRIBI Biotechnology Centre, University of Padova)

  • F. Del Rey

    (Universidad de Salamanca)

  • F. Doignon

    (LBMS, Université de Bordeaux 2, UPR CNRS 9026)

  • H. Domdey

    (Laboratorium für Molekulare Biologie, Genzentrum der LMU München)

  • E. Dubois

    (CERIA-COOVI)

  • T. Fiedler

    (Justus-Liebig-Universität Giessen, Institut für Mikro- und Molekularbiologie)

  • U. Fleig

    (Justus-Liebig-Universität Giessen, Institut für Mikro- und Molekularbiologie)

  • M. Floeth

    (QIAGEN GmbH)

  • C. Fritz

    (QIAGEN GmbH)

  • C. Gaillardin

    (Institut National Agronomique Paris-Grignon, Laboratoire de Génétique Moléculaire et Cellulaire, Centre de Biotechnologies Agro-Industrielles)

  • J. M. Garcia-Cantalejo

    (Centro de Biologia Molecular, CSIC & UAM, Cantoblanco)

  • N. N Glansdorff

    (CERIA-COOVI)

  • A. Goffeau

    (Université Catholique de Louvain)

  • U. Gueldener

    (Justus-Liebig-Universität Giessen, Institut für Mikro- und Molekularbiologie)

  • C. Herbert

    (Centre de Génétique Moléculaire, Laboratoire propre du CNRS associé à l’Université Pierre et Marie Curie)

  • K. Heumann

    (Martinsrieder Institut für Protein Sequenzen, Max-Planck-Institut für Biochemie)

  • D. Heuss-Neitzel

    (QIAGEN GmbH)

  • H. Hilbert

    (QIAGEN GmbH)

  • K. Hinni

    (Institute for Applied Microbiology, Biozentrum, University of Basel)

  • I. Iraqui Houssaini

    (Université Libre de Bruxelles, Physiologie Cellulaire et Génétique des Levures, Boulevard du Triompe CP244)

  • M. Jacquet

    (Université Paris-Sud, Institut de Génétique et Microbiologie, Laboratoire Information Génétique et Développement, Bât. 400)

  • A. Jimenez

    (Centro de Biologia Molecular, CSIC & UAM, Cantoblanco)

  • J.-L. Jonniaux

    (Université Catholique de Louvain)

  • L. Karpfinger

    (Martinsrieder Institut für Protein Sequenzen, Max-Planck-Institut für Biochemie)

  • G. Lanfranchi

    (CRIBI Biotechnology Centre, University of Padova)

  • A. Lepingle

    (Institut National Agronomique Paris-Grignon, Laboratoire de Génétique Moléculaire et Cellulaire, Centre de Biotechnologies Agro-Industrielles)

  • H. Levesque

    (Institut National Agronomique Paris-Grignon, Laboratoire de Génétique Moléculaire et Cellulaire, Centre de Biotechnologies Agro-Industrielles)

  • R. Lyck

    (Justus-Liebig-Universität Giessen, Institut für Mikro- und Molekularbiologie)

  • M. Maftahi

    (Institut National Agronomique Paris-Grignon, Laboratoire de Génétique Moléculaire et Cellulaire, Centre de Biotechnologies Agro-Industrielles)

  • L. Mallet

    (Université Paris-Sud, Institut de Génétique et Microbiologie, Laboratoire Information Génétique et Développement, Bât. 400)

  • K. C. T. Maurer

    (IMBW, BioCentrum Amsterdam)

  • F. Messenguy

    (CERIA-COOVI)

  • H. W. Mewes

    (Martinsrieder Institut für Protein Sequenzen, Max-Planck-Institut für Biochemie)

  • D. Möstl

    (QIAGEN GmbH)

  • F. Nasr

    (Centre de Génétique Moléculaire, Laboratoire propre du CNRS associé à l’Université Pierre et Marie Curie)

  • J.-M. Nicaud

    (Institut National Agronomique Paris-Grignon, Laboratoire de Génétique Moléculaire et Cellulaire, Centre de Biotechnologies Agro-Industrielles)

  • R. K. Niedenthal

    (Justus-Liebig-Universität Giessen, Institut für Mikro- und Molekularbiologie)

  • D. Pandolfo

    (CRIBI Biotechnology Centre, University of Padova)

  • A. Piérard

    (CERIA-COOVI)

  • E. Piravandi

    (Laboratorium für Molekulare Biologie, Genzentrum der LMU München)

  • R. J. Planta

    (IMBW, BioCentrum Amsterdam)

  • T. M. Pohl

    (GATC-Gesellschaft für Analyse-Technik und Consulting mbH)

  • B. Purnelle

    (Université Catholique de Louvain)

  • C. Rebischung

    (Institute for Applied Microbiology, Biozentrum, University of Basel)

  • M. Remacha

    (Centro de Biologia Molecular, CSIC & UAM, Cantoblanco)

  • J. L. Revuelta

    (Universidad de Salamanca)

  • M. Rinke

    (Laboratorium für Molekulare Biologie, Genzentrum der LMU München)

  • J. E. Saiz

    (Universidad de Salamanca)

  • F. Sartorello

    (CRIBI Biotechnology Centre, University of Padova)

  • B. Scherens

    (CERIA-COOVI)

  • M. Sen-Gupta

    (Justus-Liebig-Universität Giessen, Institut für Mikro- und Molekularbiologie)

  • A. Soler-Mira

    (Centro de Biologia Molecular, CSIC & UAM, Cantoblanco)

  • J. H. M. Urbanus

    (IMBW, BioCentrum Amsterdam)

  • G. Valle

    (CRIBI Biotechnology Centre, University of Padova)

  • L. Van Dyck

    (Université Catholique de Louvain)

  • P. Verhasselt

    (Katholieke Universiteit Leuven, Laboratory of Gene Technology)

  • F. Vierendeels

    (CERIA-COOVI)

  • S. Vissers

    (Université Libre de Bruxelles, Physiologie Cellulaire et Génétique des Levures, Boulevard du Triompe CP244)

  • M. Voet

    (Katholieke Universiteit Leuven, Laboratory of Gene Technology)

  • G. Volckaert

    (Katholieke Universiteit Leuven, Laboratory of Gene Technology)

  • A. Wach

    (Institute for Applied Microbiology, Biozentrum, University of Basel)

  • R. Wambutt

    (AGON GmbH)

  • H. Wedler

    (AGON GmbH)

  • A. Zollner

    (Martinsrieder Institut für Protein Sequenzen, Max-Planck-Institut für Biochemie)

  • J. Hani

    (Martinsrieder Institut für Protein Sequenzen, Max-Planck-Institut für Biochemie)

Abstract

In 1992 we started assembling an ordered library of cosmid clones from chromosome XIV of the yeast Saccharomyces cerevisiae. At that time, only 49 genes were known to be located on this chromosome1 and we estimated that 80% to 90% of its genes were yet to be discovered. In 1993, a team of 20 European laboratories began the systematic sequence analysis of chromosome XIV. The completed and intensively checked final sequence of 784,328 base pairs was released in April, 1996 (ref. 2). Substantial parts had been published before3–22 or had previously been made available on request. The sequence contained 419 known or presumptive protein-coding genes, including two pseudogenes and three retrotransposons, 14 tRNA genes, and three small nuclear RNA genes. For 116 (30%) protein-coding sequences, one or more structural homologues were identified elsewhere in the yeast genome. Half of them belong to duplicated groups of 6–14 loosely linked genes, in most cases with conserved gene order and orientation (relaxed interchromosomal synteny). We have considered the possible evolutionary origins of this unexpected feature of yeast genome organization.

Suggested Citation

  • P. Philippsen & K. Kleine & R. Pöhlmann & A. Düsterhöft & K. Hamberg & J. H. Hegemann & B. Obermaier & L. A. Urrestarazu & R. Aert & K. Albermann & R. Altmann & B. André & V. Baladron & J. P. G. Balle, 1997. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications," Nature, Nature, vol. 387(6632), pages 93-98, May.
    • Handle: RePEc:nat:nature:v:387:y:1997:i:6632:d:10.1038_387s093
    DOI: 10.1038/387s093
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