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Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases

Author

Listed:
  • Kermit L. Carraway III

    (Beth Israel Hospital)

  • Janet L. Weber

    (The Scripps Research Institute)

  • Michelle J. Unger

    (Beth Israel Hospital)

  • Jessica Ledesma

    (The Scripps Research Institute)

  • Naichen Yu

    (The Scripps Research Institute)

  • Martin Gassmann

    (The Salk Institute
    National Institute for Medical Research)

  • Cary Lai

    (The Scripps Research Institute)

Abstract

The neuregulins (NRGs) are a family of multipotent epidermal-growth-factor-like (EGF-like) factors that arise from splice variants of a single gene. They influence the growth, differentiation, survival and fate of several cell types. We have now discovered a set of new neuregulin-like growth factors, which we call neuregulin-2 (NRG-2): these are encoded by their own gene and exhibit a distinct expression pattern in adult brain and developing heart. Like NRG-1, the EGF-like domain of the new ligands binds to both the ErbB3- and ErbB4-receptor tyrosine kinases. However, NRG-2 stimulates different ErbB-receptor tyrosine-phosphorylation profiles from NRG-1. Our results indicate that NRG-1 and NRG-2 mediate distinct biological processes by acting at different sites in tissues and eliciting different biochemical responses in cells.

Suggested Citation

  • Kermit L. Carraway III & Janet L. Weber & Michelle J. Unger & Jessica Ledesma & Naichen Yu & Martin Gassmann & Cary Lai, 1997. "Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases," Nature, Nature, vol. 387(6632), pages 512-516, May.
    • Handle: RePEc:nat:nature:v:387:y:1997:i:6632:d:10.1038_387512a0
    DOI: 10.1038/387512a0
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