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Behavioural stress facilitates the induction of long-term depression in the hippocampus

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Listed:
  • Lin Xu

    (Trinity College)

  • Roger Anwyl
  • Michael J. Rowan

    (Trinity College)

Abstract

The induction of activity-dependent persistent increases in synap-tic efficacy, such as long-term potentiation (LTP), is inhibited by behavioural stress1,2. The question arises whether stress also affects the ability to induce persistent decreases in synaptic efficacy, such as long-term depression (LTD)3–5. We now report that the induction of stable homosynaptic LTD in the CA1 area of the hippocampus of awake adult rats is facilitated, rather than inhibited, by exposure to mild naturalistic stress. The same stress blocked the induction of LTP. The effects of such stress were short lasting: acclimatization to, or removal from, the conditions that facilitated LTD induction led to a rapid loss of the ability to elicit this form of plasticity. The time window in which LTD could be reliably elicited was prolonged by inducing anaesthesia immediately after the stress. These data reveal that even brief exposure to mild stress can produce a striking shift in the susceptibility to synaptic plasticity in the awake animal.

Suggested Citation

  • Lin Xu & Roger Anwyl & Michael J. Rowan, 1997. "Behavioural stress facilitates the induction of long-term depression in the hippocampus," Nature, Nature, vol. 387(6632), pages 497-500, May.
    • Handle: RePEc:nat:nature:v:387:y:1997:i:6632:d:10.1038_387497a0
    DOI: 10.1038/387497a0
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    Cited by:

    1. Yiu Chung Tse & Rosemary C Bagot & Juliana A Hutter & Alice S Wong & Tak Pan Wong, 2011. "Modulation of Synaptic Plasticity by Stress Hormone Associates with Plastic Alteration of Synaptic NMDA Receptor in the Adult Hippocampus," PLOS ONE, Public Library of Science, vol. 6(11), pages 1-14, November.
    2. Nora Prochnow & Tina Gebing & Kerstin Ladage & Dorothee Krause-Finkeldey & Abdessamad El Ouardi & Andreas Bitz & Joachim Streckert & Volkert Hansen & Rolf Dermietzel, 2011. "Electromagnetic Field Effect or Simply Stress? Effects of UMTS Exposure on Hippocampal Longterm Plasticity in the Context of Procedure Related Hormone Release," PLOS ONE, Public Library of Science, vol. 6(5), pages 1-13, May.

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