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Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression

Author

Listed:
  • Lelia Alland

    (Department of Microbiology and Immunology
    Department of Pediatrics)

  • Rebecca Muhle

    (Department of Microbiology and Immunology)

  • Harry Hou

    (Department of Microbiology and Immunology)

  • Jason Potes

    (Department of Microbiology and Immunology)

  • Lynda Chin

    (Department of Microbiology and Immunology
    Albert Einstein College of Medicine)

  • Nicole Schreiber-Agus

    (Department of Microbiology and Immunology)

  • Ronald A. DePinho

    (Department of Microbiology and Immunology)

Abstract

Normal mammalian growth and development are highly dependent on the regulation of the expression and activity of the Myc family of transcription factors. Mxi1-mediated inhibition of Myc activities requires interaction with mammalian Sln3A or Sin3B proteins, which have been purported to act as scaffolds for additional co-repressor factors. The identification of two such Sin3-associated factors, the nuclear receptor co-repressor (N-CoR) and histone deacetylase (HD1), provides a basis for Mxi1/Sin3-induced transcriptional repression and tumour suppression.

Suggested Citation

  • Lelia Alland & Rebecca Muhle & Harry Hou & Jason Potes & Lynda Chin & Nicole Schreiber-Agus & Ronald A. DePinho, 1997. "Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression," Nature, Nature, vol. 387(6628), pages 49-55, May.
    • Handle: RePEc:nat:nature:v:387:y:1997:i:6628:d:10.1038_387049a0
    DOI: 10.1038/387049a0
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