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A complex containing N-CoR, mSln3 and histone deacetylase mediates transcriptional repression

Author

Listed:
  • Thorsten Heinzel

    (University of California)

  • Robert M. Lavinsky

    (University of California
    University of California)

  • Tina-Marie Mullen

    (University of California)

  • Mats Söderström

    (University of California)

  • Carol D. Laherty

    (Fred Hutchinson Cancer Research Center)

  • Joseph Torchia

    (University of California)

  • Wen-Ming Yang

    (University of South Florida)

  • Gyan Brard

    (University of California)

  • Sally D. Ngo

    (University of California)

  • James R. Davie

    (University of Manitoba)

  • Edward Seto

    (University of South Florida)

  • Robert N. Eisenman

    (Fred Hutchinson Cancer Research Center)

  • David W. Rose

    (University of California)

  • Christopher K. Glass

    (University of California)

  • Michael G. Rosenfeld

    (University of California)

Abstract

Transcriptional repression by nuclear receptors has been correlated to binding of the putative co-repressor, N-CoR. A complex has been identified that contains N-CoR, the Mad presumptive co-repressor mSin3, and the histone deacetylase mRPD3, and which is required for both nuclear receptor- and Mad-dependent repression, but not for repression by transcription factors of the ets-domain family. These data predict that the ligand-induced switch of heterodimeric nuclear receptors from repressor to activator functions involves the exchange of complexes containing histone deacetylases with those that have histone acetylase activity.

Suggested Citation

  • Thorsten Heinzel & Robert M. Lavinsky & Tina-Marie Mullen & Mats Söderström & Carol D. Laherty & Joseph Torchia & Wen-Ming Yang & Gyan Brard & Sally D. Ngo & James R. Davie & Edward Seto & Robert N. E, 1997. "A complex containing N-CoR, mSln3 and histone deacetylase mediates transcriptional repression," Nature, Nature, vol. 387(6628), pages 43-48, May.
    • Handle: RePEc:nat:nature:v:387:y:1997:i:6628:d:10.1038_387043a0
    DOI: 10.1038/387043a0
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