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Phenotype of mice lacking functional Deleted in colorectal cancer (Dec) gene

Author

Listed:
  • Amin Fazeli

    (Massachusetts Institute of Technology)

  • Stephanie L. Dickinson

    (Massachusetts Institute of Technology)

  • Michelle L. Hermiston

    (Washington University School of Medicine)

  • Robert V. Tighe

    (Massachusetts Institute of Technology)

  • Robert G. Steen

    (Massachusetts Institute of Technology/Whitehead Institute Genome Center)

  • Clayton G. Small

    (Massachusetts Institute of Technology)

  • Esther T. Stoeckli

    (Developmental Biology and Neuroscience, University of California)

  • Kazuko Keino-Masu

    (Developmental Biology and Neuroscience, University of California
    National Defense Medical College)

  • Masayuki Masu

    (Developmental Biology and Neuroscience, University of California)

  • Helen Rayburn

    (Massachusetts Institute of Technology)

  • Jonathan Simons

    (Johns Hopkins University)

  • Roderick T. Bronson

    (Tufts University Schools of Medicine and Veterinary Medicine)

  • Jeffrey I. Gordon

    (Washington University School of Medicine)

  • Marc Tessier-Lavigne

    (Developmental Biology and Neuroscience, University of California)

  • Robert A. Weinberg

    (Massachusetts Institute of Technology)

Abstract

The DCC (Deleted in colorectal cancer) gene was first identified as a candidate for a tumour-suppressor gene on human chromosome 18q. More recently, in vitro studies in rodents have provided evidence that DCC might function as a receptor for the axonal chemoattractant netrin-1. Inactivation of the murine Dcc gene caused defects in axonal projections that are similar to those observed in netrin-1-deficient mice but did not affect growth, differentiation, morphogenesis or tumorigenesis in mouse intestine. These observations fail to support a tumour-suppressor function for Dcc, but are consistent with the hypothesis that DCC is a component of a receptor for netrin-1.

Suggested Citation

  • Amin Fazeli & Stephanie L. Dickinson & Michelle L. Hermiston & Robert V. Tighe & Robert G. Steen & Clayton G. Small & Esther T. Stoeckli & Kazuko Keino-Masu & Masayuki Masu & Helen Rayburn & Jonathan , 1997. "Phenotype of mice lacking functional Deleted in colorectal cancer (Dec) gene," Nature, Nature, vol. 386(6627), pages 796-804, April.
    • Handle: RePEc:nat:nature:v:386:y:1997:i:6627:d:10.1038_386796a0
    DOI: 10.1038/386796a0
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