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Drosophila CBP is a co-activator of cubitus interruptus in hedgehog signalling

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  • Hiroshi Akimaru

    (Tsukuba Life Science Center, The Institute of Physical and Chemical Research (RIKEN))

  • Yang Chen

    (Oregon Health Sciences Unviersity)

  • Ping Dai

    (Tsukuba Life Science Center, The Institute of Physical and Chemical Research (RIKEN))

  • De-Xing Hou

    (Tsukuba Life Science Center, The Institute of Physical and Chemical Research (RIKEN))

  • Maki Nonaka

    (Tsukuba Life Science Center, The Institute of Physical and Chemical Research (RIKEN))

  • Sarah M. Smolik

    (Oregon Health Sciences Unviersity)

  • Steve Armstrong

    (Oregon Health Sciences Unviersity)

  • Richard H. Goodman

    (Oregon Health Sciences Unviersity)

  • Shunsuke Ishii

    (Tsukuba Life Science Center, The Institute of Physical and Chemical Research (RIKEN))

Abstract

The transcription factor CBP, originally identified as a coactivator for CREB1,2, enhances transcription mediated by many other transcription factors3–7. Mutations in the human CBP gene are associated with Rubinstein–Taybi syndrome, a haploinsufficiency disorder characterized by abnormal pattern formation8, but the mechanism by which decreased CBP levels affect pattern formation is unclear. The hedgehog (hh) signalling pathway is an important determinant of pattern formation, cubitus interruptus (ci), a component in hh signalling, encodes a transcription factor homologous to the Gli family of proteins9 and is required for induction of the hh-dependent expression of patched (ptc), decapentaplegic (dpp) and wingless (wg)10. Haploinsufficiency for the ci-related transcription factor Gli3 causes phenotypic changes in mice (known as 'extra-toes)11 and humans (Greig's cephalopolysyndactyly syndrome)12 that have similarities to Rubinstein-Taybi syndrome. Here we show that Drosophila CBP (dCBP) functions as a coactivator of Ci, suggesting that the dCBP-Ci interaction may shed light on the contribution of CBP to pattern formation in mammals.

Suggested Citation

  • Hiroshi Akimaru & Yang Chen & Ping Dai & De-Xing Hou & Maki Nonaka & Sarah M. Smolik & Steve Armstrong & Richard H. Goodman & Shunsuke Ishii, 1997. "Drosophila CBP is a co-activator of cubitus interruptus in hedgehog signalling," Nature, Nature, vol. 386(6626), pages 735-738, April.
    • Handle: RePEc:nat:nature:v:386:y:1997:i:6626:d:10.1038_386735a0
    DOI: 10.1038/386735a0
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    1. Masaki Kikuchi & Satoshi Morita & Masatoshi Wakamori & Shin Sato & Tomomi Uchikubo-Kamo & Takehiro Suzuki & Naoshi Dohmae & Mikako Shirouzu & Takashi Umehara, 2023. "Epigenetic mechanisms to propagate histone acetylation by p300/CBP," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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