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Release of gelatinase A during platelet activation mediates aggregation

Author

Listed:
  • Grzegorz Sawicki

    (University of Alberta)

  • Eduardo Salas

    (University of Alberta)

  • Jesus Murat

    (University of Alberta)

  • Helena Miszta-Lane

    (University of Alberta)

  • Marek W. Radomski

    (University of Alberta
    University of Alberta)

Abstract

Blood platelets limit blood loss at sites of vascular injury by forming a mechanical plug. They are also involved in thrombosis, atherosclerosis, inflammation and metastasis. Platelet activation is essential for these physiological and pathological reactions and depends upon their adhesion to the vessel wall and attachment to each other in the aggregation process. The two known pathways of aggregation are mediated by the release of endoperoxides/throm-boxane A2 and ADP1–3 which amplify platelet aggregation. Here we report the identification of a new pathway of aggregation which is mediated by the release of a metalloproteinase enzyme, gelatinase A.

Suggested Citation

  • Grzegorz Sawicki & Eduardo Salas & Jesus Murat & Helena Miszta-Lane & Marek W. Radomski, 1997. "Release of gelatinase A during platelet activation mediates aggregation," Nature, Nature, vol. 386(6625), pages 616-619, April.
    • Handle: RePEc:nat:nature:v:386:y:1997:i:6625:d:10.1038_386616a0
    DOI: 10.1038/386616a0
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