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Biologically erodable microspheres as potential oral drug delivery systems

Author

Listed:
  • Edith Mathiowitz

    (Brown University)

  • Jules S. Jacob

    (Brown University)

  • Yong S. Jong

    (Brown University)

  • Gerardo P. Carino

    (Brown University)

  • Donald E. Chickering

    (Sulzer Carbomedics)

  • Pravin Chaturvedi

    (Sulzer Carbomedics
    Vertex Pharmaceuticals)

  • Camilla A. Santos

    (Brown University)

  • Kavita Vijayaraghavan

    (Brown University)

  • Sean Montgomery

    (Brown University)

  • Michael Bassett

    (Brown University)

  • Craig Morrell

    (Brown University)

Abstract

Biologically adhesive delivery systems offer important advantages1–5 over conventional drug delivery systems6. Here we show that engineered polymer microspheres made of biologically erodable polymers, which display strong adhesive interactions with gastrointestinal mucus and cellular linings, can traverse both the mucosal absorptive epithelium and the follicle-associated epithelium covering the lymphoid tissue of Peyer's patches. The polymers maintain contact with intestinal epithelium for extended periods of time and actually penetrate it, through and between cells. Thus, once loaded with compounds of pharmacological interest, the microspheres could be developed as delivery systems to transfer biologically active molecules to the circulation. We show that these microspheres increase the absorption of three model substances of widely different molecular size: dicumarol, insulin and plasmid DNA.

Suggested Citation

  • Edith Mathiowitz & Jules S. Jacob & Yong S. Jong & Gerardo P. Carino & Donald E. Chickering & Pravin Chaturvedi & Camilla A. Santos & Kavita Vijayaraghavan & Sean Montgomery & Michael Bassett & Craig , 1997. "Biologically erodable microspheres as potential oral drug delivery systems," Nature, Nature, vol. 386(6623), pages 410-414, March.
    • Handle: RePEc:nat:nature:v:386:y:1997:i:6623:d:10.1038_386410a0
    DOI: 10.1038/386410a0
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