IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v386y1997i6622d10.1038_386296a0.html
   My bibliography  Save this article

Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation

Author

Listed:
  • J. Han

    (The Scripps Research Institute)

  • Y. Jiang

    (The Scripps Research Institute)

  • Z. Li

    (The Scripps Research Institute)

  • V. V. Kravchenko

    (The Scripps Research Institute)

  • R. J. Ulevitch

    (The Scripps Research Institute)

Abstract

For cells of the innate immune system to mount a host defence response to infection, they must recognize products of microbial pathogens such as lipopolysaccharide (LPS), the endotoxin secreted by Gram-negative bacteria1. These cellular responses require intracellular signalling pathways, such as the four MAP kinase (MAPK) pathways2–6. In mammalian cells the MAPK p38 is thought to play an important role in the regulation of cellular responses during infection through its effects on the expression of proinflammatory molecules7–9. One means of understanding the role of p38 in these responses is to identify proteins with functions regulated by p38-catalysed phosphorylation. Here we demonstrate a link between the p38 pathway and a member of the myocyte-enhancer factor 2 (MEF2) group of transcription factors. We found that in monocytic cells, LPS increases the transactivation activity of MEF2C10–12 through p38-catalysed phosphorylation. One consequence of MEF2C activation is increased c-jun gene transcription. Our results show that p38 may influence host defence and inflammation by maintaining the balance of c-Jun protein consumed during infection.

Suggested Citation

  • J. Han & Y. Jiang & Z. Li & V. V. Kravchenko & R. J. Ulevitch, 1997. "Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation," Nature, Nature, vol. 386(6622), pages 296-299, March.
  • Handle: RePEc:nat:nature:v:386:y:1997:i:6622:d:10.1038_386296a0
    DOI: 10.1038/386296a0
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/386296a0
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.

    File URL: https://libkey.io/10.1038/386296a0?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Jianfeng Wu & Kang Yang & Shaowei Cai & Xiaohan Zhang & Lichen Hu & Fanjia Lin & Su-qin Wu & Changchun Xiao & Wen-Hsien Liu & Jiahuai Han, 2022. "A p38α-BLIMP1 signalling pathway is essential for plasma cell differentiation," Nature Communications, Nature, vol. 13(1), pages 1-20, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:386:y:1997:i:6622:d:10.1038_386296a0. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.