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A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection

Author

Listed:
  • Hiroshi Suzuki

    (Chugai Pharmaceutical Co. Ltd
    Research Center for Advanced Science and Technology, University of Tokyo)

  • Yukiko Kurihara

    (University of Tokyo)

  • Motohiro Takeya

    (Kumamoto University School of Medicine)

  • Nobuo Kamada

    (Chugai Pharmaceutical Co. Ltd)

  • Motoyukl Kataoka

    (CSK Research Park Inc.)

  • Kouichi Jishage

    (Chugai Pharmaceutical Co. Ltd)

  • Otoya Ueda

    (Chugai Pharmaceutical Co. Ltd)

  • Hisashl Sakaguchi

    (Kumamoto University School of Medicine)

  • Takayuki Higashi

    (Kumamoto University School of Medicine)

  • Tsukasa Suzuki

    (Chugai Pharmaceutical Co. Ltd)

  • Yoshiaki Takashima

    (Chugai Pharmaceutical Co. Ltd)

  • Yoshiki Kawabe

    (Chugai Pharmaceutical Co. Ltd
    Research Center for Advanced Science and Technology, University of Tokyo)

  • Osamu Cynshi

    (Chugai Pharmaceutical Co. Ltd)

  • Youichiro Wada

    (University of Tokyo)

  • Makoto Honda

    (University of Tokyo)

  • Hiroki Kurihara

    (University of Tokyo)

  • Hiroyuki Aburatani

    (University of Tokyo)

  • Takefumi Doi

    (Osaka University)

  • Akiyo Matsumoto

    (National Institute of Health and Nutrition)

  • Sadahiro Azuma

    (The University of Tokyo)

  • Tetsuo Noda

    (Cancer Institute)

  • Yutaka Toyoda

    (Obihiro University of Agriculture and Veterinary Medicine)

  • Hiroshige Itakura

    (National Institute of Health and Nutrition)

  • Yoshio Yazaki

    (University of Tokyo)

  • Seikoh Horiuchi

    (Kumamoto University School of Medicine)

  • Kiyoshi Takahashi

    (Kumamoto University School of Medicine)

  • J. Kar Kruijt

    (Leiden University)

  • Theo J. C. van Berkel

    (Leiden University)

  • Urs P. Steinbrecher

    (University of British Columbia)

  • Shun Ishibashi

    (University of Tokyo)

  • Nobuyo Maeda

    (School of Medicine, University of North Carolina)

  • Siamon Gordon

    (University of Oxford)

  • Tatsuhiko Kodama

    (Research Center for Advanced Science and Technology, University of Tokyo)

Abstract

Macrophage type-I and type-II class-A scavenger receptors (MSR-A) are implicated in the pathological deposition of cholesterol during atherogenesis as a result of receptor-mediated uptake of modified low-density lipoproteins (mLDL)1–6. MSR-A can bind an extraordinarily wide range of ligands, including bacterial pathogens7, and also mediates cation-independent macrophage adhesion in vitro8. Here we show that targeted disruption of the MSR-A gene in mice results in a reduction in the size of atherosclerotic lesions in an animal deficient in apolipoprotein E. Macrophages from MSR-A-deficient mice show a marked decrease in mLDL uptake in vitro, whereas mLDL clearance from plasma occurs at a normal rate, indicating that there may be alternative mechanisms for removing mLDL from the circulation. In addition, MSR-A-knockout mice show an increased susceptibility to infection with Listeria monocytogenes or herpes simplex virus type-1, indicating that MSR-A may play a part in host defence against pathogens.

Suggested Citation

  • Hiroshi Suzuki & Yukiko Kurihara & Motohiro Takeya & Nobuo Kamada & Motoyukl Kataoka & Kouichi Jishage & Otoya Ueda & Hisashl Sakaguchi & Takayuki Higashi & Tsukasa Suzuki & Yoshiaki Takashima & Yoshi, 1997. "A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection," Nature, Nature, vol. 386(6622), pages 292-296, March.
    • Handle: RePEc:nat:nature:v:386:y:1997:i:6622:d:10.1038_386292a0
    DOI: 10.1038/386292a0
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    Cited by:

    1. Eri Takematsu & Miles Massidda & Jeff Auster & Po-Chih Chen & ByungGee Im & Sanjana Srinath & Sophia Canga & Aditya Singh & Marjan Majid & Michael Sherman & Andrew Dunn & Annette Graham & Patricia Mar, 2022. "Transmembrane stem cell factor protein therapeutics enhance revascularization in ischemia without mast cell activation," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

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