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Expression cloning of GABAB receptors uncovers similarity to metabotropic glutamate receptors

Author

Listed:
  • Klemens Kaupmann

    (Therapeutic Area Nervous System)

  • Katharina Huggel

    (Therapeutic Area Nervous System)

  • Jakob Heid

    (Therapeutic Area Nervous System)

  • Peter J. Flor

    (Therapeutic Area Nervous System)

  • Serge Bischoff

    (Therapeutic Area Nervous System)

  • Stuart J. Mickel

    (Therapeutic Area Nervous System)

  • Gary McMaster

    (Therapeutic Area Nervous System)

  • Christof Angst

    (Therapeutic Area Nervous System)

  • Helmut Bittiger

    (Therapeutic Area Nervous System)

  • Wolfgang Froestl

    (Therapeutic Area Nervous System)

  • Bernhard Bettler

    (Therapeutic Area Nervous System)

Abstract

GABA (γ-amino-butyric acid), the principal inhibitory neurotransmitter in the brain, signals through ionotropic (GABAA/GABAC) and metabotropic (GABAB) receptor systems. Here we report the cloning of GABAB receptors. Photoaffinity labelling experiments suggest that the cloned receptors correspond to two highly conserved GABAB receptor forms present in the vertebrate nervous system. The cloned receptors negatively couple to adenylyl cyclase and show sequence similarity to the metabotropic receptors for the excitatory neurotransmitter L-glutamate.

Suggested Citation

  • Klemens Kaupmann & Katharina Huggel & Jakob Heid & Peter J. Flor & Serge Bischoff & Stuart J. Mickel & Gary McMaster & Christof Angst & Helmut Bittiger & Wolfgang Froestl & Bernhard Bettler, 1997. "Expression cloning of GABAB receptors uncovers similarity to metabotropic glutamate receptors," Nature, Nature, vol. 386(6622), pages 239-246, March.
    • Handle: RePEc:nat:nature:v:386:y:1997:i:6622:d:10.1038_386239a0
    DOI: 10.1038/386239a0
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    Cited by:

    1. Chanjuan Xu & Yiwei Zhou & Yuxuan Liu & Li Lin & Peng Liu & Xiaomei Wang & Zhengyuan Xu & Jean-Philippe Pin & Philippe Rondard & Jianfeng Liu, 2024. "Specific pharmacological and Gi/o protein responses of some native GPCRs in neurons," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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