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Phosphorylation of RNA-binding protein controls cell cycle switch from mitotic to meiotic in fission yeast

Author

Listed:
  • Yoshinori Watanabe

    (Graduate School of Science, University of Tokyo
    Lincoln's Inn Fields)

  • Satoko Shinozaki-Yabana

    (Graduate School of Science, University of Tokyo)

  • Yuji Chikashige

    (Graduate School of Science, University of Tokyo)

  • Yasushi Hiraoka

    (Graduate School of Science, University of Tokyo)

  • Masayuki Yamamoto

    (Graduate School of Science, University of Tokyo)

Abstract

Meiosis generates haploid gametes from diploid cells and is an almost universal feature of eukaryotic organisms. But little is known about how the switch from mitotic to meiotic cell cycles is molecularly controlled. In the fission yeast Schizosaccharomyces pombe, inactivation of the protein kinase Pat1(Ran1) upon nutrient deprivation triggers entry into the meiotic cell cycle1–6. Here we show that the RNA-binding protein Mei2 is a substrate of Pat1 kinase and that dephosphorylation of Mei2 is sufficient to switch cells from the mitotic cell cycle into meiosis. Mei2 is localized mainly in the cytoplasm of proliferating cells but is seen as a single spot close to the microtubule organizing centre in prophase nuclei during meiosis. Our results, and others from a metazoan7, emphasize the crucial role of RNA-binding proteins in the initiation and execution of meiosis.

Suggested Citation

  • Yoshinori Watanabe & Satoko Shinozaki-Yabana & Yuji Chikashige & Yasushi Hiraoka & Masayuki Yamamoto, 1997. "Phosphorylation of RNA-binding protein controls cell cycle switch from mitotic to meiotic in fission yeast," Nature, Nature, vol. 386(6621), pages 187-190, March.
    • Handle: RePEc:nat:nature:v:386:y:1997:i:6621:d:10.1038_386187a0
    DOI: 10.1038/386187a0
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    Cited by:

    1. Alberto Jiménez-Martín & Alberto Pineda-Santaella & Rebeca Martín-García & Rodrigo Esteban-Villafañe & Alix Matarrese & Jesús Pinto-Cruz & Sergio Camacho-Cabañas & Daniel León-Periñán & Antonia Terriz, 2025. "Centromere positioning orchestrates telomere bouquet formation and the initiation of meiotic differentiation," Nature Communications, Nature, vol. 16(1), pages 1-19, December.

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