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Homeosis and intestinal tumours in Cdx2 mutant mice

Author

Listed:
  • K. Chawengsaksophak

    (University of Melbourne)

  • R. James

    (The Queen Elizabeth Hospital)

  • V. E. Hammond

    (University of Melbourne)

  • F. Köntgen

    (Royal Melbourne Hospital)

  • F. Beck

    (University of Melbourne)

Abstract

In Drosophila, disturbing the expression of the homeobox gene caudal causes a severe disruption in body segmentation and global body patterning1. There are three mouse homologues of Drosophila caudal: Cdx1 (ref. 2), Cdx2 (ref. 3) and Cdx4 (ref. 4). We have generated a null mutation of murine Cdx2 by homologous recombination. Cdx2 homozygote null mutants die between 3.5 and 5.5 days post coitum (d.p.c.). Cdx2 heterozygote mutants exhibit a variable phenotype, with many showing tail abnormalities or stunted growth. Skeletal analysis demonstrates a homeotic shift of vertebrae and compatible malformations of the ribs. Within the first three months of life, 90% of Cdx2 heterozygotes develop multiple intestinal adenomatous polyps, particularly in the proximal colon. These polyps occasionally contain areas of true metaplasia. In contrast to the surrounding intestinal epithelium, the neoplastic cells do not express Cdx2 from the remaining allele. These results suggest that Cdx2 mutation is the primary event in the genesis of some intestinal tumours.

Suggested Citation

  • K. Chawengsaksophak & R. James & V. E. Hammond & F. Köntgen & F. Beck, 1997. "Homeosis and intestinal tumours in Cdx2 mutant mice," Nature, Nature, vol. 386(6620), pages 84-87, March.
    • Handle: RePEc:nat:nature:v:386:y:1997:i:6620:d:10.1038_386084a0
    DOI: 10.1038/386084a0
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    Cited by:

    1. Lijing Yang & Lei Tu & Shilpa Bisht & Yiqing Mao & Daniel Petkovich & Sara-Jayne Thursby & Jinxiao Liang & Nibedita Patel & Ray-Whay Chiu Yen & Tina Largent & Cynthia Zahnow & Malcolm Brock & Kathy Ga, 2024. "Tissue-location-specific transcription programs drive tumor dependencies in colon cancer," Nature Communications, Nature, vol. 15(1), pages 1-21, December.

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