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Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein

Author

Listed:
  • Guangbin Luo

    (The University of Texas M.D. Anderson Cancer Center)

  • Patricia Ducy

    (The University of Texas M.D. Anderson Cancer Center)

  • Marc D. McKee
  • Gerald J. Pinero
  • Evelyne Loyer

    (The University of Texas M.D. Anderson Cancer Center)

  • Richard R. Behringer

    (The University of Texas M.D. Anderson Cancer Center)

  • Gérard Karsenty

    (The University of Texas M.D. Anderson Cancer Center)

Abstract

Calcification of the extracellular matrix (ECM) can be physiological or pathological. Physiological calcification occurs in bone when the soft ECM is converted into a rigid material capable of sustaining mechanical force; pathological calcification can occur in arteries1 and cartilage2 and other soft tissues. No molecular determinant regulating ECM calcification has yet been identified. A candidate molecule is matrix GLA protein (Mgp), a mineral-binding ECM protein3 synthesized by vascular smooth-muscle cells and chondrocytes, two cell types that produce an uncalcified ECM. Mice that lack Mgp develop to term but die within two months as a result of arterial calcification which leads to bloodvessel rupture. Chondrocytes that elaborate a typical cartilage matrix can be seen in the affected arteries. Mgp-deficient mice additionally exhibit inappropriate calcification of various cartilages, including the growth plate, which eventually leads to short stature, osteopenia and fractures. These results indicate that ECM calcification must be actively inhibited in soft tissues. To our knowledge, Mgp is the first inhibitor of calcification of arteries and cartilage to be characterized in vivo.

Suggested Citation

  • Guangbin Luo & Patricia Ducy & Marc D. McKee & Gerald J. Pinero & Evelyne Loyer & Richard R. Behringer & Gérard Karsenty, 1997. "Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein," Nature, Nature, vol. 386(6620), pages 78-81, March.
    • Handle: RePEc:nat:nature:v:386:y:1997:i:6620:d:10.1038_386078a0
    DOI: 10.1038/386078a0
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    Cited by:

    1. Philipp Hendrix & Nelson Sofoluke & Matthew Adams & Saran Kunaprayoon & Ramin Zand & Amy N Kolinovsky & Thomas N Person & Mudit Gupta & Oded Goren & H Lester Kirchner & Clemens M Schirmer & Natalia S , 2020. "Matrix Gla protein polymorphism rs1800801 associates with recurrence of ischemic stroke," PLOS ONE, Public Library of Science, vol. 15(6), pages 1-10, June.
    2. Arvind Ponnusamy & Smeeta Sinha & Gareth D Hyde & Samantha J Borland & Rebecca F Taylor & Emma Pond & Heather J Eyre & Colette A Inkson & Andrew Gilmore & Nick Ashton & Philip A Kalra & Ann E Canfield, 2018. "FTI-277 inhibits smooth muscle cell calcification by up-regulating PI3K/Akt signaling and inhibiting apoptosis," PLOS ONE, Public Library of Science, vol. 13(4), pages 1-18, April.

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