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The nuclear receptor homologue Ftz-F1 and the homeodomain protein Ftz are mutually dependent cofactors

Author

Listed:
  • Antoine Guichet

    (European Molecular Biology Laboratory)

  • John W. R. Copeland

    (University of Toronto, Charles H. Best Institute)

  • Miklós Erdélyi

    (European Molecular Biology Laboratory
    Institute of Genetics)

  • Daniela Hlousek

    (University of Toronto, Charles H. Best Institute)

  • Péter Závorszky

    (European Molecular Biology Laboratory)

  • Jacqueline Ho

    (University of Western Ontario)

  • Susan Brown

    (Kansas State University)

  • Anthony Percival-Smith

    (University of Western Ontario)

  • Henry M. Krause

    (University of Toronto, Charles H. Best Institute)

  • Anne Ephrussi

    (European Molecular Biology Laboratory)

Abstract

Nuclear hormone receptors and homeodomain proteins are two classes of transcription factor that regulate major developmental processes. Both depend on interactions with other proteins for specificity and activity. The Drosophila gene fushi tarazu (ftz)y which encodes a homeodomain protein1 (Ftz), is required zygo-tically for the formation of alternate segments in the developing embryo2. Here we show that the orphan nuclear receptor α Ftz-Fl (ref. 3), which is deposited in the egg during oogenesis4, is an obligatory cofactor for Ftz. The two proteins interact specifically and directly, both in vitro and in vivo, through a conserved domain in the Ftz polypeptide. This interaction suggests that other nuclear receptor/homeodomain protein interactions maybe important and common in developing organisms.

Suggested Citation

  • Antoine Guichet & John W. R. Copeland & Miklós Erdélyi & Daniela Hlousek & Péter Závorszky & Jacqueline Ho & Susan Brown & Anthony Percival-Smith & Henry M. Krause & Anne Ephrussi, 1997. "The nuclear receptor homologue Ftz-F1 and the homeodomain protein Ftz are mutually dependent cofactors," Nature, Nature, vol. 385(6616), pages 548-552, February.
    • Handle: RePEc:nat:nature:v:385:y:1997:i:6616:d:10.1038_385548a0
    DOI: 10.1038/385548a0
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    Cited by:

    1. Zhaojiang Guo & Le Guo & Jianying Qin & Fan Ye & Dan Sun & Qingjun Wu & Shaoli Wang & Neil Crickmore & Xuguo Zhou & Alejandra Bravo & Mario Soberón & Youjun Zhang, 2022. "A single transcription factor facilitates an insect host combating Bacillus thuringiensis infection while maintaining fitness," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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