IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v22y2003i20d10.1093_emboj_cdg542.html
   My bibliography  Save this article

EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer

Author

Listed:
  • Adrian P. Bracken

    (European Institute of Oncology)

  • Diego Pasini

    (European Institute of Oncology)

  • Maria Capra

    (European Institute of Oncology
    FIRC Institute of Molecular Oncology)

  • Elena Prosperini

    (European Institute of Oncology)

  • Elena Colli

    (European Institute of Oncology)

  • Kristian Helin

    (European Institute of Oncology
    FIRC Institute of Molecular Oncology)

Abstract

Recent experiments have demonstrated that the Polycomb group (PcG) gene EZH2 is highly expressed in metastatic prostate cancer and in lymphomas. EZH2 is a component of the PRC2 histone methyltransferase complex, which also contains EED and SUZ12 and is required for the silencing of HOX gene expression during embryonic development. Here we demonstrate that both EZH2 and EED are essential for the proliferation of both transformed and non‐transformed human cells. In addition, the pRB‐E2F pathway tightly regulates their expression and, consistent with this, we find that EZH2 is highly expressed in a large set of human tumors. These results raise the question whether EZH2 is a marker of proliferation or if it is actually contributing to tumor formation. Significantly, we propose that EZH2 is a bona fide oncogene, since we find that ectopic expression of EZH2 is capable of providing a proliferative advantage to primary cells and, in addition, its gene locus is specifically amplified in several primary tumors.

Suggested Citation

  • Adrian P. Bracken & Diego Pasini & Maria Capra & Elena Prosperini & Elena Colli & Kristian Helin, 2003. "EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer," Nature, Nature, vol. 22(20), pages 5323-5335, October.
    • Handle: RePEc:nat:nature:v:22:y:2003:i:20:d:10.1093_emboj_cdg542
    DOI: 10.1093/emboj/cdg542
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/EMBJ7595452
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1093/emboj/cdg542?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Keywords

    E2F; EED; EZH2; Polycomb; pRB;
    All these keywords.

    JEL classification:

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:22:y:2003:i:20:d:10.1093_emboj_cdg542. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.