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Inconsistent embryo selection across polygenic score methods

Author

Listed:
  • Shinichi Namba

    (The University of Tokyo
    Osaka University
    RIKEN Center for Integrative Medical Sciences)

  • Masato Akiyama

    (Kyushu University)

  • Haruka Hamanoue

    (Yokohama City University Hospital)

  • Kazuto Kato

    (Osaka University)

  • Minae Kawashima

    (ROIS-DS)

  • Itaru Kushima

    (Nagoya University Graduate School of Medicine
    Nagoya University Hospital)

  • Koichi Matsuda

    (The University of Tokyo
    The University of Tokyo)

  • Masahiro Nakatochi

    (Nagoya University Graduate School of Medicine)

  • Soichi Ogishima

    (Tohoku University
    Tohoku University)

  • Kyuto Sonehara

    (The University of Tokyo
    Osaka University
    RIKEN Center for Integrative Medical Sciences)

  • Ken Suzuki

    (Osaka University)

  • Atsushi Takata

    (RIKEN Center for Brain Science)

  • Gen Tamiya

    (Tohoku University Graduate School of Medicine
    Tohoku University
    RIKEN Center for Advanced Intelligence Project)

  • Chizu Tanikawa

    (The University of Tokyo)

  • Kenichi Yamamoto

    (Osaka University
    Osaka University
    Osaka University
    Osaka University)

  • Natsuko Yamamoto

    (Osaka University
    Osaka University
    and Social Issues (ELSI Center))

  • Norio Ozaki

    (Nagoya University Graduate School of Medicine)

  • Yukinori Okada

    (The University of Tokyo
    Osaka University
    RIKEN Center for Integrative Medical Sciences
    Osaka University)

Abstract

Private enterprises offer preimplantation genetic testing with polygenic scores to select embryos with ‘desirable’ potential. In silico simulations using biobank resources show that the selected embryo would rely substantially on the choice of polygenic score method and randomness in score construction, which raises ethical concerns.

Suggested Citation

  • Shinichi Namba & Masato Akiyama & Haruka Hamanoue & Kazuto Kato & Minae Kawashima & Itaru Kushima & Koichi Matsuda & Masahiro Nakatochi & Soichi Ogishima & Kyuto Sonehara & Ken Suzuki & Atsushi Takata, 2024. "Inconsistent embryo selection across polygenic score methods," Nature Human Behaviour, Nature, vol. 8(12), pages 2264-2267, December.
    • Handle: RePEc:nat:nathum:v:8:y:2024:i:12:d:10.1038_s41562-024-02019-y
    DOI: 10.1038/s41562-024-02019-y
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