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Maternal adiposity and perinatal and offspring outcomes: an umbrella review

Author

Listed:
  • Ziyi Yang

    (Shandong University)

  • Gengchen Feng

    (Shandong University)

  • Xueying Gao

    (Shandong University
    Shanghai Jiao Tong University School of Medicine
    Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics)

  • Xueqi Yan

    (Shandong University)

  • Yimeng Li

    (Shandong University)

  • Yuteng Wang

    (Shandong University)

  • Shumin Li

    (Shandong University
    Shanghai Jiao Tong University School of Medicine
    Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics)

  • Yonghui Jiang

    (Shandong University)

  • Shigang Zhao

    (Shandong University
    Shandong University
    Ministry of Education
    Shandong Technology Innovation Center for Reproductive Health)

  • Han Zhao

    (Shandong University
    Shandong University
    Ministry of Education
    Shandong Technology Innovation Center for Reproductive Health)

  • Zi-Jiang Chen

    (Shandong University
    Shandong University
    Shanghai Jiao Tong University School of Medicine
    Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics)

Abstract

Maternal adiposity deleteriously affects obstetrical health and has been associated with long-term adverse consequences in offspring. Here we conducted an umbrella review encompassing 194 observational meta-analyses, 10 Mendelian randomization studies and 748 interventional meta-analyses to appraise the published evidence on the associations between maternal adiposity and perinatal and offspring outcomes. Evidence grading suggested that 17 (8.8%) observational meta-analyses were supported by convincing evidence for 12 outcomes: maternal adiposity was associated with an increased risk of caesarean delivery following labour induction, infant mortality, Apgar score

Suggested Citation

  • Ziyi Yang & Gengchen Feng & Xueying Gao & Xueqi Yan & Yimeng Li & Yuteng Wang & Shumin Li & Yonghui Jiang & Shigang Zhao & Han Zhao & Zi-Jiang Chen, 2024. "Maternal adiposity and perinatal and offspring outcomes: an umbrella review," Nature Human Behaviour, Nature, vol. 8(12), pages 2406-2422, December.
    • Handle: RePEc:nat:nathum:v:8:y:2024:i:12:d:10.1038_s41562-024-01994-6
    DOI: 10.1038/s41562-024-01994-6
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