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Structural and functional asymmetry of the neonatal cerebral cortex

Author

Listed:
  • Logan Z. J. Williams

    (King’s College London
    King’s College London)

  • Sean P. Fitzgibbon

    (University of Oxford, John Radcliffe Hospital)

  • Jelena Bozek

    (University of Zagreb)

  • Anderson M. Winkler

    (National Institute of Mental Health, National Institutes of Health)

  • Ralica Dimitrova

    (King’s College London)

  • Tanya Poppe

    (King’s College London)

  • Andreas Schuh

    (Imperial College London)

  • Antonios Makropoulos

    (King’s College London)

  • John Cupitt

    (Imperial College London)

  • Jonathan O’Muircheartaigh

    (King’s College London
    King’s College London
    King’s College London)

  • Eugene P. Duff

    (University of Oxford, John Radcliffe Hospital
    Imperial College London)

  • Lucilio Cordero-Grande

    (King’s College London
    Universidad Politécnica de Madrid and CIBER-BBN, ISCIII)

  • Anthony N. Price

    (King’s College London
    King’s College London)

  • Joseph V. Hajnal

    (King’s College London
    King’s College London)

  • Daniel Rueckert

    (Imperial College London
    Technical University of Munich)

  • Stephen M. Smith

    (University of Oxford, John Radcliffe Hospital)

  • A. David Edwards

    (King’s College London
    King’s College London
    Evelina London Children’s Hospital)

  • Emma C. Robinson

    (King’s College London
    King’s College London)

Abstract

Features of brain asymmetry have been implicated in a broad range of cognitive processes; however, their origins are still poorly understood. Here we investigated cortical asymmetries in 442 healthy term-born neonates using structural and functional magnetic resonance images from the Developing Human Connectome Project. Our results demonstrate that the neonatal cortex is markedly asymmetric in both structure and function. Cortical asymmetries observed in the term cohort were contextualized in two ways: by comparing them against cortical asymmetries observed in 103 preterm neonates scanned at term-equivalent age, and by comparing structural asymmetries against those observed in 1,110 healthy young adults from the Human Connectome Project. While associations with preterm birth and biological sex were minimal, significant differences exist between birth and adulthood.

Suggested Citation

  • Logan Z. J. Williams & Sean P. Fitzgibbon & Jelena Bozek & Anderson M. Winkler & Ralica Dimitrova & Tanya Poppe & Andreas Schuh & Antonios Makropoulos & John Cupitt & Jonathan O’Muircheartaigh & Eugen, 2023. "Structural and functional asymmetry of the neonatal cerebral cortex," Nature Human Behaviour, Nature, vol. 7(6), pages 942-955, June.
    • Handle: RePEc:nat:nathum:v:7:y:2023:i:6:d:10.1038_s41562-023-01542-8
    DOI: 10.1038/s41562-023-01542-8
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