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Multiscale temporal integration organizes hierarchical computation in human auditory cortex

Author

Listed:
  • Sam V. Norman-Haignere

    (Columbia University
    Life Sciences Research Foundation
    Howard Hughes Medical Institute
    University of Rochester Medical Center)

  • Laura K. Long

    (Columbia University
    Columbia University)

  • Orrin Devinsky

    (NYU Langone Medical Center
    NYU Langone Medical Center)

  • Werner Doyle

    (NYU Langone Medical Center
    NYU Langone Medical Center)

  • Ifeoma Irobunda

    (Columbia University Irving Medical Center)

  • Edward M. Merricks

    (Columbia University Irving Medical Center)

  • Neil A. Feldstein

    (Columbia University Irving Medical Center)

  • Guy M. McKhann

    (Columbia University Irving Medical Center)

  • Catherine A. Schevon

    (Columbia University Irving Medical Center)

  • Adeen Flinker

    (NYU Langone Medical Center
    NYU Langone Medical Center
    NYU Tandon School of Engineering)

  • Nima Mesgarani

    (Columbia University
    Columbia University
    Columbia University)

Abstract

To derive meaning from sound, the brain must integrate information across many timescales. What computations underlie multiscale integration in human auditory cortex? Evidence suggests that auditory cortex analyses sound using both generic acoustic representations (for example, spectrotemporal modulation tuning) and category-specific computations, but the timescales over which these putatively distinct computations integrate remain unclear. To answer this question, we developed a general method to estimate sensory integration windows—the time window when stimuli alter the neural response—and applied our method to intracranial recordings from neurosurgical patients. We show that human auditory cortex integrates hierarchically across diverse timescales spanning from ~50 to 400 ms. Moreover, we find that neural populations with short and long integration windows exhibit distinct functional properties: short-integration electrodes (less than ~200 ms) show prominent spectrotemporal modulation selectivity, while long-integration electrodes (greater than ~200 ms) show prominent category selectivity. These findings reveal how multiscale integration organizes auditory computation in the human brain.

Suggested Citation

  • Sam V. Norman-Haignere & Laura K. Long & Orrin Devinsky & Werner Doyle & Ifeoma Irobunda & Edward M. Merricks & Neil A. Feldstein & Guy M. McKhann & Catherine A. Schevon & Adeen Flinker & Nima Mesgara, 2022. "Multiscale temporal integration organizes hierarchical computation in human auditory cortex," Nature Human Behaviour, Nature, vol. 6(3), pages 455-469, March.
  • Handle: RePEc:nat:nathum:v:6:y:2022:i:3:d:10.1038_s41562-021-01261-y
    DOI: 10.1038/s41562-021-01261-y
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    Cited by:

    1. Ediz Sohoglu & Loes Beckers & Matthew H. Davis, 2024. "Convergent neural signatures of speech prediction error are a biological marker for spoken word recognition," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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