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Genome-wide association study identifies 48 common genetic variants associated with handedness

Author

Listed:
  • Gabriel Cuellar-Partida

    (The University of Queensland
    23andMe, Inc.)

  • Joyce Y. Tung

    (23andMe, Inc.)

  • Nicholas Eriksson

    (23andMe, Inc.)

  • Eva Albrecht

    (Helmholtz Zentrum München—German Research Center for Environmental Health)

  • Fazil Aliev

    (Virginia Commonwealth University
    Karabuk University, Faculty of Business)

  • Ole A. Andreassen

    (University of Oslo
    Oslo University Hospital)

  • Inês Barroso

    (Wellcome Sanger Institute
    University of Cambridge
    University of Cambridge)

  • Jacques S. Beckmann

    (Centre Hospitalier Universitaire Vaudois and University of Lausanne)

  • Marco P. Boks

    (University Utrecht)

  • Dorret I. Boomsma

    (Vrije Universiteit
    Amsterdam University Medical Centers)

  • Heather A. Boyd

    (Statens Serum Institut)

  • Monique M. B. Breteler

    (German Center for Neurodegenerative Diseases (DZNE))

  • Harry Campbell

    (University of Edinburgh)

  • Daniel I. Chasman

    (Brigham and Women’s Hospital
    Harvard Medical School)

  • Lynn F. Cherkas

    (King’s College London)

  • Gail Davies

    (University of Edinburgh
    University of Edinburgh)

  • Eco J. C. Geus

    (Vrije Universiteit
    Amsterdam University Medical Centers)

  • Ian J. Deary

    (University of Edinburgh
    University of Edinburgh)

  • Panos Deloukas

    (Queen Mary University of London)

  • Danielle M. Dick

    (Virginia Commonwealth University
    Virginia Commonwealth University)

  • David L. Duffy

    (QIMR Berghofer Medical Research Institute)

  • Johan G. Eriksson

    (University of Helsinki and Helsinki University Hospital
    Folkhälsan Research Center
    Singapore Institute for Clinical Sciences, Agency for Science Technology and Research
    National University of Singapore)

  • Tõnu Esko

    (University of Tartu
    Broad Institute of MIT and Harvard)

  • Bjarke Feenstra

    (Statens Serum Institut)

  • Frank Geller

    (Statens Serum Institut)

  • Christian Gieger

    (Institute of Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental Health
    München–Neuherberg)

  • Ina Giegling

    (Martin-Luther-University Halle-Wittenberg)

  • Scott D. Gordon

    (QIMR Berghofer Medical Research Institute)

  • Jiali Han

    (Indiana University
    Indiana University)

  • Thomas F. Hansen

    (Mental Health Services of Copenhagen
    Copenhagen University Hospital)

  • Annette M. Hartmann

    (Martin-Luther-University Halle-Wittenberg)

  • Caroline Hayward

    (University of Edinburgh)

  • Kauko Heikkilä

    (University of Helsinki)

  • Andrew A. Hicks

    (Eurac Research)

  • Joel N. Hirschhorn

    (Boston Children’s Hospital
    Harvard Medical School
    Broad Institute)

  • Jouke-Jan Hottenga

    (Vrije Universiteit
    Amsterdam University Medical Centers)

  • Jennifer E. Huffman

    (University of Edinburgh)

  • Liang-Dar Hwang

    (The University of Queensland)

  • M. Arfan Ikram

    (University Medical Center)

  • Jaakko Kaprio

    (University of Helsinki
    University of Helsinki)

  • John P. Kemp

    (The University of Queensland
    University of Bristol)

  • Kay-Tee Khaw

    (University of Cambridge)

  • Norman Klopp

    (Hannover Medical School)

  • Bettina Konte

    (Martin-Luther-University Halle-Wittenberg)

  • Zoltan Kutalik

    (University of Lausanne
    Swiss Institute of Bioinformatics)

  • Jari Lahti

    (University of Helsinki
    University of Turku
    University of Helsinki)

  • Xin Li

    (Indiana University
    Indiana University)

  • Ruth J. F. Loos

    (University of Cambridge
    Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai)

  • Michelle Luciano

    (University of Edinburgh
    University of Edinburgh)

  • Sigurdur H. Magnusson

    (deCODE Genetics)

  • Massimo Mangino

    (King’s College London)

  • Pedro Marques-Vidal

    (Lausanne University Hospital and University of Lausanne)

  • Nicholas G. Martin

    (QIMR Berghofer Medical Research Institute)

  • Wendy L. McArdle

    (University of Bristol)

  • Mark I. McCarthy

    (University of Oxford
    University of Oxford
    Oxford University Hospitals Trust
    Genentech)

  • Carolina Medina-Gomez

    (University Medical Center
    University Medical Center)

  • Mads Melbye

    (Statens Serum Institut
    University of Copenhagen
    Stanford University School of Medicine)

  • Scott A. Melville

    (Eurac Research)

  • Andres Metspalu

    (University of Tartu)

  • Lili Milani

    (University of Tartu)

  • Vincent Mooser

    (Lausanne University Hospital and University of Lausanne)

  • Mari Nelis

    (University of Tartu)

  • Dale R. Nyholt

    (QIMR Berghofer Medical Research Institute
    Queensland University of Technology)

  • Kevin S. O’Connell

    (University of Oslo)

  • Roel A. Ophoff

    (University California Los Angeles
    University California Los Angeles
    Erasmus University Medical Center)

  • Cameron Palmer

    (Columbia University)

  • Aarno Palotie

    (University of Helsinki)

  • Teemu Palviainen

    (University of Helsinki)

  • Guillaume Pare

    (McMaster University)

  • Lavinia Paternoster

    (University of Bristol)

  • Leena Peltonen

    (University of Helsinki)

  • Brenda W. J. H. Penninx

    (Amsterdam University Medical Centers
    VU University)

  • Ozren Polasek

    (University of Split School of Medicine
    Psychiatric Hospital Sveti Ivan)

  • Peter P. Pramstaller

    (Eurac Research)

  • Inga Prokopenko

    (University of Surrey
    Imperial College London)

  • Katri Raikkonen

    (University of Helsinki)

  • Samuli Ripatti

    (University of Helsinki)

  • Fernando Rivadeneira

    (University Medical Center
    University Medical Center)

  • Igor Rudan

    (University of Edinburgh)

  • Dan Rujescu

    (Martin-Luther-University Halle-Wittenberg)

  • Johannes H. Smit

    (Amsterdam University Medical Centers
    VU University)

  • George Davey Smith

    (University of Bristol)

  • Jordan W. Smoller

    (Massachusetts General Hospital
    Broad Institute)

  • Nicole Soranzo

    (Wellcome Sanger Institute)

  • Tim D. Spector

    (King’s College London)

  • Beate St Pourcain

    (University of Bristol
    Max Planck Institute for Psycholinguistics, Wundtlaan
    Radboud University)

  • John M. Starr

    (University of Edinburgh
    University of Edinburgh)

  • Hreinn Stefánsson

    (deCODE Genetics)

  • Stacy Steinberg

    (deCODE Genetics)

  • Maris Teder-Laving

    (University of Tartu)

  • Gudmar Thorleifsson

    (deCODE Genetics)

  • Kári Stefánsson

    (deCODE Genetics)

  • Nicholas J. Timpson

    (University of Bristol)

  • André G. Uitterlinden

    (University Medical Center
    University Medical Center)

  • Cornelia M. Duijn

    (University Medical Center
    University Medical Center)

  • Frank J. A. Rooij

    (University Medical Center)

  • Jaqueline M. Vink

    (Vrije Universiteit
    Radboud University)

  • Peter Vollenweider

    (Lausanne University Hospital and University of Lausanne)

  • Eero Vuoksimaa

    (University of Helsinki)

  • Gérard Waeber

    (Lausanne University Hospital and University of Lausanne)

  • Nicholas J. Wareham

    (University of Cambridge)

  • Nicole Warrington

    (The University of Queensland)

  • Dawn Waterworth

    (GlaxoSmithKline)

  • Thomas Werge

    (Mental Health Services of Copenhagen
    University of Copenhagen
    The Lundbeck Foundation’s IPSYCH Initiative)

  • H.-Erich Wichmann

    (Helmholtz Center)

  • Elisabeth Widen

    (University of Helsinki)

  • Gonneke Willemsen

    (Vrije Universiteit)

  • Alan F. Wright

    (University of Edinburgh)

  • Margaret J. Wright

    (The University of Queensland
    The University of Queensland)

  • Mousheng Xu

    (Harvard Medical School)

  • Jing Hua Zhao

    (University of Cambridge)

  • Peter Kraft

    (Harvard Medical School)

  • David A. Hinds

    (23andMe, Inc.)

  • Cecilia M. Lindgren

    (University of Oxford
    University of Oxford)

  • Reedik Mägi

    (University of Tartu)

  • Benjamin M. Neale

    (Broad Institute of MIT and Harvard
    Massachusetts General Hospital)

  • David M. Evans

    (The University of Queensland
    University of Bristol)

  • Sarah E. Medland

    (The University of Queensland
    QIMR Berghofer Medical Research Institute)

Abstract

Handedness has been extensively studied because of its relationship with language and the over-representation of left-handers in some neurodevelopmental disorders. Using data from the UK Biobank, 23andMe and the International Handedness Consortium, we conducted a genome-wide association meta-analysis of handedness (N = 1,766,671). We found 41 loci associated (P

Suggested Citation

  • Gabriel Cuellar-Partida & Joyce Y. Tung & Nicholas Eriksson & Eva Albrecht & Fazil Aliev & Ole A. Andreassen & Inês Barroso & Jacques S. Beckmann & Marco P. Boks & Dorret I. Boomsma & Heather A. Boyd , 2021. "Genome-wide association study identifies 48 common genetic variants associated with handedness," Nature Human Behaviour, Nature, vol. 5(1), pages 59-70, January.
    • Handle: RePEc:nat:nathum:v:5:y:2021:i:1:d:10.1038_s41562-020-00956-y
    DOI: 10.1038/s41562-020-00956-y
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    Citations

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    Cited by:

    1. Dick Schijven & Sourena Soheili-Nezhad & Simon E. Fisher & Clyde Francks, 2024. "Exome-wide analysis implicates rare protein-altering variants in human handedness," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    2. Loïc Labache & Tian Ge & B. T. Thomas Yeo & Avram J. Holmes, 2023. "Language network lateralization is reflected throughout the macroscale functional organization of cortex," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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