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New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders

Author

Listed:
  • Evangelos Evangelou

    (Imperial College London
    University of Ioannina Medical School)

  • He Gao

    (Imperial College London
    Imperial College London)

  • Congying Chu

    (King’s College London)

  • Georgios Ntritsos

    (University of Ioannina Medical School)

  • Paul Blakeley

    (Imperial College London
    Imperial College London)

  • Andrew R. Butts

    (University of Utah)

  • Raha Pazoki

    (Imperial College London)

  • Hideaki Suzuki

    (Imperial College London
    Tohoku University)

  • Fotios Koskeridis

    (University of Ioannina Medical School)

  • Andrianos M. Yiorkas

    (Brunel University London
    Imperial College London)

  • Ibrahim Karaman

    (Imperial College London
    Imperial College London)

  • Joshua Elliott

    (Imperial College London)

  • Qiang Luo

    (Fudan University
    University of Cambridge)

  • Stefanie Aeschbacher

    (University Hospital Basel)

  • Traci M. Bartz

    (University of Washington
    University of Washington)

  • Sebastian E. Baumeister

    (University Medicine Greifswald
    Ludwig-Maximilians-Universitat Munchen, UNIKA-T Augsburg)

  • Peter S. Braund

    (University of Leicester, Cardiovascular Research Centre, Glenfield Hospital
    NIHR Leicester Biomedical Research Centre, Glenfield Hospital)

  • Michael R. Brown

    (The University of Texas Health Science Center at Houston)

  • Jennifer A. Brody

    (University of Washington)

  • Toni-Kim Clarke

    (University of Edinburgh)

  • Niki Dimou

    (University of Ioannina Medical School)

  • Jessica D. Faul

    (University of Michigan)

  • Georg Homuth

    (University Medicine Greifswald)

  • Anne U. Jackson

    (University of Michigan)

  • Katherine A. Kentistou

    (University of Edinburgh
    University of Edinburgh)

  • Peter K. Joshi

    (University of Edinburgh)

  • Rozenn N. Lemaitre

    (University of Washington)

  • Penelope A. Lind

    (QIMR Berghofer Medical Research Institute)

  • Leo-Pekka Lyytikäinen

    (Fimlab Laboratories
    Tampere University
    Tampere University Hospital)

  • Massimo Mangino

    (King’s College London
    NIHR Biomedical Research Centre, Guy’s and St Thomas Foundation Trust)

  • Yuri Milaneschi

    (Amsterdam University Medical Center)

  • Christopher P. Nelson

    (University of Leicester, Cardiovascular Research Centre, Glenfield Hospital
    NIHR Leicester Biomedical Research Centre, Glenfield Hospital)

  • Ilja M. Nolte

    (University Medical Center Groningen, University of Groningen)

  • Mia-Maria Perälä

    (Folkhälsan Research Center
    National Institute for Health and Welfare)

  • Ozren Polasek

    (University of Split)

  • David Porteous

    (University of Edinburgh
    Centre for Cognitive Ageing and Cognitive Epidemiology)

  • Scott M. Ratliff

    (University of Michigan)

  • Jennifer A. Smith

    (University of Michigan
    University of Michigan)

  • Alena Stančáková

    (University of Eastern Finland)

  • Alexander Teumer

    (University Medicine Greifswald
    German Centre for Cardiovascular Research (DZHK), partner site Greifswald)

  • Samuli Tuominen

    (University of Helsinki)

  • Sébastien Thériault

    (McMaster University
    Laval University)

  • Jagadish Vangipurapu

    (University of Eastern Finland)

  • John B. Whitfield

    (QIMR Berghofer Medical Research Institute)

  • Alexis Wood

    (Baylor College of Medicine)

  • Jie Yao

    (Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center)

  • Bing Yu

    (The University of Texas Health Science Center at Houston)

  • Wei Zhao

    (University of Michigan)

  • Dan E. Arking

    (Johns Hopkins University School of Medicine)

  • Juha Auvinen

    (University of Oulu
    Oulunkaari Health Center)

  • Chunyu Liu

    (Boston University School of Public Health)

  • Minna Männikkö

    (University of Oulu)

  • Lorenz Risch

    (University Hospital, University of Bern
    Labormedizinisches Zentrum Dr. Risch
    Private University of the Principality of Liechtenstein)

  • Jerome I. Rotter

    (Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center)

  • Harold Snieder

    (University Medical Center Groningen, University of Groningen)

  • Juha Veijola

    (University of Oulu
    University Hospital of Oulu
    University and University Hospital of Oulu)

  • Alexandra I. Blakemore

    (Brunel University London
    Imperial College London)

  • Michael Boehnke

    (University of Michigan)

  • Harry Campbell

    (University of Edinburgh)

  • David Conen

    (McMaster University)

  • Johan G. Eriksson

    (University of Helsinki
    National Institute for Health and Welfare
    Helsinki University Central Hospital)

  • Hans J. Grabe

    (University Medicine Greifswald
    German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald)

  • Xiuqing Guo

    (Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center)

  • Pim Harst

    (University Medical Center Groningen, University of Groningen
    University Medical Center Groningen, University of Groningen
    Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute)

  • Catharina A. Hartman

    (University Medical Center Groningen, University of Groningen)

  • Caroline Hayward

    (University of Edinburgh, Western General Hospital)

  • Andrew C. Heath

    (Washington University in St Louis)

  • Marjo-Riitta Jarvelin

    (Imperial College London
    University of Oulu
    University of Oulu
    Oulu University Hospital, OYS)

  • Mika Kähönen

    (Tampere University Hospital
    Tampere University)

  • Sharon L. R. Kardia

    (University of Michigan)

  • Michael Kühne

    (University Hospital Basel)

  • Johanna Kuusisto

    (University of Eastern Finland and Kuopio University Hospital)

  • Markku Laakso

    (University of Eastern Finland and Kuopio University Hospital)

  • Jari Lahti

    (University of Helsinki)

  • Terho Lehtimäki

    (Fimlab Laboratories
    Tampere University)

  • Andrew M. McIntosh

    (University of Edinburgh
    Centre for Cognitive Ageing and Cognitive Epidemiology)

  • Karen L. Mohlke

    (University of North Carolina)

  • Alanna C. Morrison

    (The University of Texas Health Science Center at Houston)

  • Nicholas G. Martin

    (QIMR Berghofer Medical Research Institute)

  • Albertine J. Oldehinkel

    (University Medical Center Groningen, University of Groningen)

  • Brenda W. J. H. Penninx

    (Amsterdam University Medical Center)

  • Bruce M. Psaty

    (University of Washington
    Kaiser Permanente Washington Health Research Institute)

  • Olli T. Raitakari

    (Turku University Hospital
    University of Turku
    University of Turku and Turku University Hospital)

  • Igor Rudan

    (University of Edinburgh)

  • Nilesh J. Samani

    (University of Leicester, Cardiovascular Research Centre, Glenfield Hospital
    NIHR Leicester Biomedical Research Centre, Glenfield Hospital)

  • Laura J. Scott

    (University of Michigan)

  • Tim D. Spector

    (King’s College London)

  • Niek Verweij

    (University Medical Center Groningen, University of Groningen)

  • David R. Weir

    (University of Michigan)

  • James F. Wilson

    (University of Edinburgh
    University of Edinburgh, Western General Hospital)

  • Daniel Levy

    (Framingham Heart Study
    National Institutes of Health)

  • Ioanna Tzoulaki

    (Imperial College London
    Imperial College London)

  • Jimmy D. Bell

    (University of Westminster)

  • Paul M. Matthews

    (Imperial College London
    Imperial College London)

  • Adrian Rothenfluh

    (University of Utah
    University of Utah)

  • Sylvane Desrivières

    (King’s College London)

  • Gunter Schumann

    (King’s College London
    Fudan University)

  • Paul Elliott

    (Imperial College London
    Imperial College London
    Imperial College London
    Imperial College Healthcare NHS Trust and Imperial College London)

Abstract

Excessive alcohol consumption is one of the main causes of death and disability worldwide. Alcohol consumption is a heritable complex trait. Here we conducted a meta-analysis of genome-wide association studies of alcohol consumption (g d−1) from the UK Biobank, the Alcohol Genome-Wide Consortium and the Cohorts for Heart and Aging Research in Genomic Epidemiology Plus consortia, collecting data from 480,842 people of European descent to decipher the genetic architecture of alcohol intake. We identified 46 new common loci and investigated their potential functional importance using magnetic resonance imaging data and gene expression studies. We identify genetic pathways associated with alcohol consumption and suggest genetic mechanisms that are shared with neuropsychiatric disorders such as schizophrenia.

Suggested Citation

  • Evangelos Evangelou & He Gao & Congying Chu & Georgios Ntritsos & Paul Blakeley & Andrew R. Butts & Raha Pazoki & Hideaki Suzuki & Fotios Koskeridis & Andrianos M. Yiorkas & Ibrahim Karaman & Joshua E, 2019. "New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders," Nature Human Behaviour, Nature, vol. 3(9), pages 950-961, September.
    • Handle: RePEc:nat:nathum:v:3:y:2019:i:9:d:10.1038_s41562-019-0653-z
    DOI: 10.1038/s41562-019-0653-z
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    Cited by:

    1. Merete Ellingjord-Dale & Nikos Papadimitriou & Michail Katsoulis & Chew Yee & Niki Dimou & Dipender Gill & Dagfinn Aune & Jue-Sheng Ong & Stuart MacGregor & Benjamin Elsworth & Sarah J Lewis & Richard, 2021. "Coffee consumption and risk of breast cancer: A Mendelian randomization study," PLOS ONE, Public Library of Science, vol. 16(1), pages 1-15, January.

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