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Identification of neurobehavioural symptom groups based on shared brain mechanisms

Author

Listed:
  • Alex Ing

    (King’s College London)

  • Philipp G. Sämann

    (Max Planck Institute of Psychiatry)

  • Congying Chu

    (King’s College London)

  • Nicole Tay

    (King’s College London)

  • Francesca Biondo

    (King’s College London)

  • Gabriel Robert

    (King’s College London
    University of Rennes)

  • Tianye Jia

    (King’s College London)

  • Thomas Wolfers

    (Radboud University Nijmegen)

  • Sylvane Desrivières

    (King’s College London)

  • Tobias Banaschewski

    (Heidelberg University)

  • Arun L. W. Bokde

    (Trinity College Dublin)

  • Uli Bromberg

    (University Medical Centre Hamburg−Eppendorf)

  • Christian Büchel

    (University Medical Centre Hamburg−Eppendorf
    Stanford University)

  • Patricia Conrod

    (Institute of Psychiatry, Psychology & Neuroscience King’s College London
    Université de Montréal)

  • Tahmine Fadai

    (University Medical Centre Hamburg−Eppendorf)

  • Herta Flor

    (Heidelberg University
    University of Mannheim)

  • Vincent Frouin

    (Université Paris−Saclay)

  • Hugh Garavan

    (University of Vermont)

  • Philip A. Spechler

    (University of Vermont)

  • Penny Gowland

    (University of Nottingham)

  • Yvonne Grimmer

    (Heidelberg University)

  • Andreas Heinz

    (Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health)

  • Bernd Ittermann

    (Physikalisch-Technische Bundesanstalt)

  • Viola Kappel

    (Humboldt University)

  • Jean-Luc Martinot

    (Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 Neuroimaging & Psychiatry, University Paris Saclay, University Paris Descartes; DIgiteo-Labs, Gif-sur-Yvette; and Maison de Solenn)

  • Andreas Meyer-Lindenberg

    (Heidelberg University)

  • Sabina Millenet

    (Heidelberg University)

  • Frauke Nees

    (Heidelberg University
    Heidelberg University)

  • Betteke Noort

    (Humboldt University)

  • Dimitri Papadopoulos Orfanos

    (Université Paris−Saclay)

  • Marie-Laure Paillère Martinot

    (Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 Neuroimaging & Psychiatry, University Paris Saclay, University Paris Descartes; DIgiteo-Labs
    Pitié-Salpêtrière Hospital)

  • Jani Penttilä

    (Psychosocial Services Adolescent Outpatient Clinic)

  • Luise Poustka

    (University Medical Centre Göttingen)

  • Erin Burke Quinlan

    (King’s College London)

  • Michael N. Smolka

    (Technische Universität Dresden)

  • Argyris Stringaris

    (King’s College London
    National Institute of Mental Health/NIH)

  • Maren Struve

    (Technische Universität Dresden)

  • Ilya M. Veer

    (Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health)

  • Henrik Walter

    (Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health)

  • Robert Whelan

    (Trinity College Dublin)

  • Ole A. Andreassen

    (Oslo University Hospital
    University of Oslo)

  • Ingrid Agartz

    (University of Oslo
    Diakonhjemmet Hospital
    Karolinska Institutet)

  • Hervé Lemaitre

    (Institut National de la Santé et de la Recherche Médicale, UMR 992 INSERM, CEA, Faculté de médecine, Université Paris-Sud, Université Paris-Saclay, NeuroSpin)

  • Edward D. Barker

    (King’s College London
    King’s College London)

  • John Ashburner

    (University College London)

  • Elisabeth Binder

    (Max Planck Institute of Psychiatry)

  • Jan Buitelaar

    (Radboud University Nijmegen)

  • Andre Marquand

    (Radboud University Nijmegen)

  • Trevor W. Robbins

    (University of Cambridge)

  • Gunter Schumann

    (King’s College London
    Campus Charite Mitte, Humboldt University, Berlin and Leibniz Institute for Neurobiology
    Fudan University
    Humboldt University)

Abstract

Most psychopathological disorders develop in adolescence. The biological basis for this development is poorly understood. To enhance diagnostic characterization and develop improved targeted interventions, it is critical to identify behavioural symptom groups that share neural substrates. We ran analyses to find relationships between behavioural symptoms and neuroimaging measures of brain structure and function in adolescence. We found two symptom groups, consisting of anxiety/depression and executive dysfunction symptoms, respectively, that correlated with distinct sets of brain regions and inter-regional connections, measured by structural and functional neuroimaging modalities. We found that the neural correlates of these symptom groups were present before behavioural symptoms had developed. These neural correlates showed case–control differences in corresponding psychiatric disorders, depression and attention deficit hyperactivity disorder in independent clinical samples. By characterizing behavioural symptom groups based on shared neural mechanisms, our results provide a framework for developing a classification system for psychiatric illness that is based on quantitative neurobehavioural measures.

Suggested Citation

  • Alex Ing & Philipp G. Sämann & Congying Chu & Nicole Tay & Francesca Biondo & Gabriel Robert & Tianye Jia & Thomas Wolfers & Sylvane Desrivières & Tobias Banaschewski & Arun L. W. Bokde & Uli Bromberg, 2019. "Identification of neurobehavioural symptom groups based on shared brain mechanisms," Nature Human Behaviour, Nature, vol. 3(12), pages 1306-1318, December.
    • Handle: RePEc:nat:nathum:v:3:y:2019:i:12:d:10.1038_s41562-019-0738-8
    DOI: 10.1038/s41562-019-0738-8
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