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Exome sequencing of healthy phenotypic extremes links TROVE2 to emotional memory and PTSD

Author

Listed:
  • Angela Heck

    (University of Basel
    Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel
    Psychiatric University Clinics, University of Basel)

  • Annette Milnik

    (University of Basel
    Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel
    Psychiatric University Clinics, University of Basel)

  • Vanja Vukojevic

    (University of Basel
    Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel
    Life Sciences Training Facility, University of Basel)

  • Jana Petrovska

    (University of Basel
    Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel)

  • Tobias Egli

    (University of Basel
    Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel)

  • Jochen Singer

    (ETH Zurich
    SIB Swiss Institute of Bioinformatics)

  • Pablo Escobar

    (SIB Swiss Institute of Bioinformatics
    University of Basel
    sciCORE Center for Scientific Computing, University of Basel)

  • Thierry Sengstag

    (SIB Swiss Institute of Bioinformatics
    University of Basel
    sciCORE Center for Scientific Computing, University of Basel)

  • David Coynel

    (Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel
    University of Basel)

  • Virginie Freytag

    (University of Basel
    Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel)

  • Matthias Fastenrath

    (Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel
    University of Basel)

  • Philippe Demougin

    (University of Basel
    Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel
    Life Sciences Training Facility, University of Basel)

  • Eva Loos

    (Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel
    University of Basel)

  • Francina Hartmann

    (University of Basel
    Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel)

  • Nathalie Schicktanz

    (Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel
    University of Basel)

  • Bernardo Delarue Bizzini

    (University of Basel
    Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel
    Life Sciences Training Facility, University of Basel)

  • Christian Vogler

    (University of Basel
    Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel
    Psychiatric University Clinics, University of Basel)

  • Iris-Tatjana Kolassa

    (Clinical & Biological Psychology, Institute of Psychology & Education, Ulm University)

  • Sarah Wilker

    (Clinical & Biological Psychology, Institute of Psychology & Education, Ulm University)

  • Thomas Elbert

    (University of Konstanz)

  • Torsten Schwede

    (SIB Swiss Institute of Bioinformatics
    University of Basel
    sciCORE Center for Scientific Computing, University of Basel)

  • Christian Beisel

    (ETH Zurich)

  • Niko Beerenwinkel

    (ETH Zurich
    SIB Swiss Institute of Bioinformatics)

  • Dominique J.-F. de Quervain

    (Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel
    Psychiatric University Clinics, University of Basel
    University of Basel)

  • Andreas Papassotiropoulos

    (University of Basel
    Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel
    Psychiatric University Clinics, University of Basel
    Life Sciences Training Facility, University of Basel)

Abstract

Many mental disorders represent the extremes of the normal distribution of traits, which are related to multiple cognitive and emotional dimensions. By performing whole-exome sequencing of healthy, young subjects with extremely high versus extremely low aversive memory performance, we identified TROVE2 as a gene implicated in emotional memory in health and disease. TROVE2 encodes Ro60, a broadly expressed RNA-binding protein implicated in the regulation of inflammatory gene expression and autoimmunity. A regulatory TROVE2 variant was linked to higher emotional memory capacity and higher emotional memory-related brain activation in healthy subjects. In addition, TROVE2 was associated with traumatic memory and the frequency of post-traumatic stress disorder in genocide survivors.

Suggested Citation

  • Angela Heck & Annette Milnik & Vanja Vukojevic & Jana Petrovska & Tobias Egli & Jochen Singer & Pablo Escobar & Thierry Sengstag & David Coynel & Virginie Freytag & Matthias Fastenrath & Philippe Demo, 2017. "Exome sequencing of healthy phenotypic extremes links TROVE2 to emotional memory and PTSD," Nature Human Behaviour, Nature, vol. 1(4), pages 1-10, April.
    • Handle: RePEc:nat:nathum:v:1:y:2017:i:4:d:10.1038_s41562-017-0081
    DOI: 10.1038/s41562-017-0081
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