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Molybdenum-based nanoclusters act as antioxidants and ameliorate acute kidney injury in mice

Author

Listed:
  • Dalong Ni

    (University of Wisconsin)

  • Dawei Jiang

    (University of Wisconsin
    Shenzhen University)

  • Christopher J. Kutyreff

    (University of Wisconsin)

  • Jianhao Lai

    (University of Wisconsin
    Peking University Health Science Center)

  • Yongjun Yan

    (University of Wisconsin)

  • Todd E. Barnhart

    (University of Wisconsin)

  • Bo Yu

    (University of Wisconsin)

  • Hyung-Jun Im

    (University of Wisconsin)

  • Lei Kang

    (University of Wisconsin)

  • Steve Y. Cho

    (University of Wisconsin)

  • Zhaofei Liu

    (Peking University Health Science Center)

  • Peng Huang

    (Shenzhen University)

  • Jonathan W. Engle

    (University of Wisconsin)

  • Weibo Cai

    (University of Wisconsin
    University of Wisconsin Carbone Cancer Center)

Abstract

Acute kidney injury (AKI) is a common reactive oxygen species (ROS)-related renal disease that causes numerous deaths annually, yet only supportive treatment is currently available in the clinics. Development of antioxidants with high accumulation rates in kidneys is highly desired to help prevent AKI. Here we report molybdenum-based polyoxometalate (POM) nanoclusters with preferential renal uptake as novel nano-antioxidants for kidney protection. These POM nanoclusters, with a readily variable valence state of molybdenum ions, possess the capability to scavenge detrimental ROS. Our results demonstrate that POM nanoclusters can efficiently alleviate clinical symptoms in mice subjected to AKI, as verified by dynamic PET imaging with 68Ga-EDTA, serum tests, kidney tissue staining, and biomarkers detection in the kidneys. The protective effect of POM nanoclusters against AKI in living animals suggests exploring their use for the treatment of AKI patients, as well as patients with other ROS-related diseases.

Suggested Citation

  • Dalong Ni & Dawei Jiang & Christopher J. Kutyreff & Jianhao Lai & Yongjun Yan & Todd E. Barnhart & Bo Yu & Hyung-Jun Im & Lei Kang & Steve Y. Cho & Zhaofei Liu & Peng Huang & Jonathan W. Engle & Weibo, 2018. "Molybdenum-based nanoclusters act as antioxidants and ameliorate acute kidney injury in mice," Nature Communications, Nature, vol. 9(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-07890-8
    DOI: 10.1038/s41467-018-07890-8
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    Cited by:

    1. Ting Wang & Mingru Bai & Wei Geng & Mohsen Adeli & Ling Ye & Chong Cheng, 2025. "Bioinspired artificial antioxidases for efficient redox homeostasis and maxillofacial bone regeneration," Nature Communications, Nature, vol. 16(1), pages 1-20, December.

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