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Oxygen-dependent proteolysis regulates the stability of angiosperm polycomb repressive complex 2 subunit VERNALIZATION 2

Author

Listed:
  • Daniel J. Gibbs

    (University of Birmingham)

  • Hannah M. Tedds

    (University of Birmingham)

  • Anne-Marie Labandera

    (University of Birmingham)

  • Mark Bailey

    (University of Birmingham)

  • Mark D. White

    (University of Oxford)

  • Sjon Hartman

    (Utrecht University)

  • Colleen Sprigg

    (University of Birmingham)

  • Sophie L. Mogg

    (University of Birmingham)

  • Rory Osborne

    (University of Birmingham)

  • Charlene Dambire

    (University of Nottingham)

  • Tinne Boeckx

    (University of Nottingham)

  • Zachary Paling

    (University of Birmingham)

  • Laurentius A. C. J. Voesenek

    (Utrecht University)

  • Emily Flashman

    (University of Oxford)

  • Michael J. Holdsworth

    (University of Nottingham)

Abstract

The polycomb repressive complex 2 (PRC2) regulates epigenetic gene repression in eukaryotes. Mechanisms controlling its developmental specificity and signal-responsiveness are poorly understood. Here, we identify an oxygen-sensitive N-terminal (N-) degron in the plant PRC2 subunit VERNALIZATION(VRN) 2, a homolog of animal Su(z)12, that promotes its degradation via the N-end rule pathway. We provide evidence that this N-degron arose early during angiosperm evolution via gene duplication and N-terminal truncation, facilitating expansion of PRC2 function in flowering plants. We show that proteolysis via the N-end rule pathway prevents ectopic VRN2 accumulation, and that hypoxia and long-term cold exposure lead to increased VRN2 abundance, which we propose may be due to inhibition of VRN2 turnover via its N-degron. Furthermore, we identify an overlap in the transcriptional responses to hypoxia and prolonged cold, and show that VRN2 promotes tolerance to hypoxia. Our work reveals a mechanism for post-translational regulation of VRN2 stability that could potentially link environmental inputs to the epigenetic control of plant development.

Suggested Citation

  • Daniel J. Gibbs & Hannah M. Tedds & Anne-Marie Labandera & Mark Bailey & Mark D. White & Sjon Hartman & Colleen Sprigg & Sophie L. Mogg & Rory Osborne & Charlene Dambire & Tinne Boeckx & Zachary Palin, 2018. "Oxygen-dependent proteolysis regulates the stability of angiosperm polycomb repressive complex 2 subunit VERNALIZATION 2," Nature Communications, Nature, vol. 9(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-07875-7
    DOI: 10.1038/s41467-018-07875-7
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    Cited by:

    1. Agata Zubrycka & Charlene Dambire & Laura Dalle Carbonare & Gunjan Sharma & Tinne Boeckx & Kamal Swarup & Craig J. Sturrock & Brian S. Atkinson & Ranjan Swarup & Françoise Corbineau & Neil J. Oldham &, 2023. "ERFVII action and modulation through oxygen-sensing in Arabidopsis thaliana," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

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