IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v9y2018i1d10.1038_s41467-018-07779-6.html
   My bibliography  Save this article

Genomic insights into multidrug-resistance, mating and virulence in Candida auris and related emerging species

Author

Listed:
  • José F. Muñoz

    (Broad Institute of MIT and Harvard)

  • Lalitha Gade

    (Centers for Disease Control and Prevention)

  • Nancy A. Chow

    (Centers for Disease Control and Prevention)

  • Vladimir N. Loparev

    (Centers for Disease Control and Prevention)

  • Phalasy Juieng

    (Centers for Disease Control and Prevention)

  • Elizabeth L. Berkow

    (Centers for Disease Control and Prevention)

  • Rhys A. Farrer

    (Broad Institute of MIT and Harvard)

  • Anastasia P. Litvintseva

    (Centers for Disease Control and Prevention)

  • Christina A. Cuomo

    (Broad Institute of MIT and Harvard)

Abstract

Candida auris is an emergent multidrug-resistant fungal pathogen causing increasing reports of outbreaks. While distantly related to C. albicans and C. glabrata, C. auris is closely related to rarely observed and often multidrug-resistant species from the C. haemulonii clade. Here, we analyze near complete genome assemblies for the four C. auris clades and three related species, and map intra- and inter-species rearrangements across the seven chromosomes. Using RNA-Seq-guided gene predictions, we find that most mating and meiosis genes are conserved and that clades contain either the MTLa or MTLα mating loci. Comparing the genomes of these emerging species to those of other Candida species identifies genes linked to drug resistance and virulence, including expanded families of transporters and lipases, as well as mutations and copy number variants in ERG11. Gene expression analysis identifies transporters and metabolic regulators specific to C. auris and those conserved with related species which may contribute to differences in drug response in this emerging fungal clade.

Suggested Citation

  • José F. Muñoz & Lalitha Gade & Nancy A. Chow & Vladimir N. Loparev & Phalasy Juieng & Elizabeth L. Berkow & Rhys A. Farrer & Anastasia P. Litvintseva & Christina A. Cuomo, 2018. "Genomic insights into multidrug-resistance, mating and virulence in Candida auris and related emerging species," Nature Communications, Nature, vol. 9(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-07779-6
    DOI: 10.1038/s41467-018-07779-6
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-018-07779-6
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-018-07779-6?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-07779-6. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.