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Blood flow-induced Notch activation and endothelial migration enable vascular remodeling in zebrafish embryos

Author

Listed:
  • Bart Weijts

    (University of California-San Diego
    University of California-San Diego)

  • Edgar Gutierrez

    (University of California-San Diego
    MuWells Inc)

  • Semion K. Saikin

    (Harvard University)

  • Ararat J. Ablooglu

    (University of California-San Diego)

  • David Traver

    (University of California-San Diego)

  • Alex Groisman

    (University of California-San Diego)

  • Eugene Tkachenko

    (University of California-San Diego
    MuWells Inc)

Abstract

Arteries and veins are formed independently by different types of endothelial cells (ECs). In vascular remodeling, arteries and veins become connected and some arteries become veins. It is unclear how ECs in transforming vessels change their type and how fates of individual vessels are determined. In embryonic zebrafish trunk, vascular remodeling transforms arterial intersegmental vessels (ISVs) into a functional network of arteries and veins. Here we find that, once an ISV is connected to venous circulation, venous blood flow promotes upstream migration of ECs that results in displacement of arterial ECs by venous ECs, completing the transformation of this ISV into a vein without trans-differentiation of ECs. Arterial blood flow initiated in two neighboring ISVs prevents their transformation into veins by activating Notch signaling in ECs. Together, different responses of ECs to arterial and venous blood flow lead to formation of a balanced network with equal numbers of arteries and veins.

Suggested Citation

  • Bart Weijts & Edgar Gutierrez & Semion K. Saikin & Ararat J. Ablooglu & David Traver & Alex Groisman & Eugene Tkachenko, 2018. "Blood flow-induced Notch activation and endothelial migration enable vascular remodeling in zebrafish embryos," Nature Communications, Nature, vol. 9(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-07732-7
    DOI: 10.1038/s41467-018-07732-7
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    Cited by:

    1. Laetitia Préau & Anna Lischke & Melanie Merkel & Neslihan Oegel & Maria Weissenbruch & Andria Michael & Hongryeol Park & Dietmar Gradl & Christian Kupatt & Ferdinand Noble, 2024. "Parenchymal cues define Vegfa-driven venous angiogenesis by activating a sprouting competent venous endothelial subtype," Nature Communications, Nature, vol. 15(1), pages 1-22, December.

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