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PDL2+ CD11b+ dermal dendritic cells capture topical antigen through hair follicles to prime LAP+ Tregs

Author

Listed:
  • Leticia Tordesillas

    (Pediatric Allergy & Immunology, Icahn School of Medicine at Mount Sinai
    Immunology Institute. Icahn School of Medicine at Mount Sinai)

  • Daniel Lozano-Ojalvo

    (Pediatric Allergy & Immunology, Icahn School of Medicine at Mount Sinai
    Immunology Institute. Icahn School of Medicine at Mount Sinai)

  • David Dunkin

    (Pediatric Gastroenterology, Icahn School of Medicine at Mount Sinai)

  • Lucie Mondoulet

    (DBV Technologies)

  • Judith Agudo

    (Immunology Institute. Icahn School of Medicine at Mount Sinai)

  • Miriam Merad

    (Immunology Institute. Icahn School of Medicine at Mount Sinai)

  • Hugh A. Sampson

    (Pediatric Allergy & Immunology, Icahn School of Medicine at Mount Sinai
    Immunology Institute. Icahn School of Medicine at Mount Sinai
    DBV Technologies)

  • M. Cecilia Berin

    (Pediatric Allergy & Immunology, Icahn School of Medicine at Mount Sinai
    Immunology Institute. Icahn School of Medicine at Mount Sinai)

Abstract

The skin immune system must discriminate between innocuous antigens and pathogens. Antigen applied topically using a Viaskin® patch elicits immune tolerance that can suppress colitis and food allergy. Here we show how topical antigen is acquired and presented by dendritic cells in the skin. Topical antigen is acquired by Langerhans cells (LC) and CD11b+ cDC2s but not cDC1s, and both LCs and CD11b+ cDC2s reaching the lymph node can prime T cells and expand LAP+ Tregs. However, LCs are neither required nor sufficient for T cell priming, and have no role in tolerance induction. Conversely, IRF-4-dependent cDC2s are required for T cell priming. Acquisition of antigen in the dermis, delivery to the draining lymph node, and generation of tolerance are all absent in hairless mice. These results indicate an important function for hair follicle niche and CD11b+ cDC2s in antigen acquisition, and in generation of primary immune tolerance to topical antigens.

Suggested Citation

  • Leticia Tordesillas & Daniel Lozano-Ojalvo & David Dunkin & Lucie Mondoulet & Judith Agudo & Miriam Merad & Hugh A. Sampson & M. Cecilia Berin, 2018. "PDL2+ CD11b+ dermal dendritic cells capture topical antigen through hair follicles to prime LAP+ Tregs," Nature Communications, Nature, vol. 9(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-07716-7
    DOI: 10.1038/s41467-018-07716-7
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