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Role of NS1 antibodies in the pathogenesis of acute secondary dengue infection

Author

Listed:
  • Deshni Jayathilaka

    (University of Sri Jayewardenepura)

  • Laksiri Gomes

    (University of Sri Jayewardenepura)

  • Chandima Jeewandara

    (University of Sri Jayewardenepura)

  • Geethal. S. Bandara Jayarathna

    (University of Sri Jayewardenepura)

  • Dhanushka Herath

    (University of Sri Jayewardenepura)

  • Pathum Asela Perera

    (University of Sri Jayewardenepura)

  • Samitha Fernando

    (University of Sri Jayewardenepura)

  • Ananda Wijewickrama

    (National Institute of Infectious Diseases)

  • Clare S. Hardman

    (Oxford NIHR Biomedical Research Centre)

  • Graham S. Ogg

    (Oxford NIHR Biomedical Research Centre)

  • Gathsaurie Neelika Malavige

    (University of Sri Jayewardenepura
    Oxford NIHR Biomedical Research Centre)

Abstract

The role of NS1-specific antibodies in the pathogenesis of dengue virus infection is poorly understood. Here we investigate the immunoglobulin responses of patients with dengue fever (DF) and dengue hemorrhagic fever (DHF) to NS1. Antibody responses to recombinant-NS1 are assessed in serum samples throughout illness of patients with acute secondary DENV1 and DENV2 infection by ELISA. NS1 antibody titres are significantly higher in patients with DHF compared to those with DF for both serotypes, during the critical phase of illness. Furthermore, during both acute secondary DENV1 and DENV2 infection, the antibody repertoire of DF and DHF patients is directed towards distinct regions of the NS1 protein. In addition, healthy individuals, with past non-severe dengue infection have a similar antibody repertoire as those with mild acute infection (DF). Therefore, antibodies that target specific NS1 epitopes could predict disease severity and be of potential benefit in aiding vaccine and treatment design.

Suggested Citation

  • Deshni Jayathilaka & Laksiri Gomes & Chandima Jeewandara & Geethal. S. Bandara Jayarathna & Dhanushka Herath & Pathum Asela Perera & Samitha Fernando & Ananda Wijewickrama & Clare S. Hardman & Graham , 2018. "Role of NS1 antibodies in the pathogenesis of acute secondary dengue infection," Nature Communications, Nature, vol. 9(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-07667-z
    DOI: 10.1038/s41467-018-07667-z
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