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Microtubule asters anchored by FSD1 control axoneme assembly and ciliogenesis

Author

Listed:
  • Hai-Qing Tu

    (National Center of Biomedical Analysis)

  • Xuan-He Qin

    (National Center of Biomedical Analysis)

  • Zhi-Bin Liu

    (University of Chinese Academy of Science
    Chinese Academy of Sciences)

  • Zeng-Qing Song

    (National Center of Biomedical Analysis)

  • Huai-Bin Hu

    (National Center of Biomedical Analysis)

  • Yu-Cheng Zhang

    (National Center of Biomedical Analysis)

  • Yan Chang

    (National Center of Biomedical Analysis)

  • Min Wu

    (National Center of Biomedical Analysis)

  • Yan Huang

    (National Center of Biomedical Analysis)

  • Yun-Feng Bai

    (National Center of Biomedical Analysis)

  • Guang Wang

    (National Center of Biomedical Analysis)

  • Qiu-Ying Han

    (National Center of Biomedical Analysis)

  • Ai-Ling Li

    (National Center of Biomedical Analysis)

  • Tao Zhou

    (National Center of Biomedical Analysis)

  • Feng Liu

    (Chinese Academy of Sciences)

  • Xue-Min Zhang

    (National Center of Biomedical Analysis)

  • Hui-Yan Li

    (National Center of Biomedical Analysis
    The First Hospital of Jilin University)

Abstract

Defective ciliogenesis causes human developmental diseases termed ciliopathies. Microtubule (MT) asters originating from centrosomes in mitosis ensure the fidelity of cell division by positioning the spindle apparatus. However, the function of microtubule asters in interphase remains largely unknown. Here, we reveal an essential role of MT asters in transition zone (TZ) assembly during ciliogenesis. We demonstrate that the centrosome protein FSD1, whose biological function is largely unknown, anchors MT asters to interphase centrosomes by binding to microtubules. FSD1 knockdown causes defective ciliogenesis and affects embryonic development in vertebrates. We further show that disruption of MT aster anchorage by depleting FSD1 or other known anchoring proteins delocalizes the TZ assembly factor Cep290 from centriolar satellites, and causes TZ assembly defects. Thus, our study establishes FSD1 as a MT aster anchorage protein and reveals an important function of MT asters anchored by FSD1 in TZ assembly during ciliogenesis.

Suggested Citation

  • Hai-Qing Tu & Xuan-He Qin & Zhi-Bin Liu & Zeng-Qing Song & Huai-Bin Hu & Yu-Cheng Zhang & Yan Chang & Min Wu & Yan Huang & Yun-Feng Bai & Guang Wang & Qiu-Ying Han & Ai-Ling Li & Tao Zhou & Feng Liu &, 2018. "Microtubule asters anchored by FSD1 control axoneme assembly and ciliogenesis," Nature Communications, Nature, vol. 9(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-07664-2
    DOI: 10.1038/s41467-018-07664-2
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