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Islr regulates canonical Wnt signaling-mediated skeletal muscle regeneration by stabilizing Dishevelled-2 and preventing autophagy

Author

Listed:
  • Kuo Zhang

    (China Agricultural University
    China Agricultural University)

  • Yuying Zhang

    (China Agricultural University)

  • Lijie Gu

    (China Agricultural University)

  • Miaomiao Lan

    (China Agricultural University)

  • Chuncheng Liu

    (China Agricultural University)

  • Meng Wang

    (China Agricultural University)

  • Yang Su

    (China Agricultural University)

  • Mengxu Ge

    (China Agricultural University)

  • Tongtong Wang

    (China Agricultural University)

  • Yingying Yu

    (China Agricultural University)

  • Chang Liu

    (China Agricultural University)

  • Lei Li
  • Qiuyan Li

    (China Agricultural University)

  • Yaofeng Zhao

    (China Agricultural University)

  • Zhengquan Yu

    (China Agricultural University)

  • Fudi Wang

    (China Agricultural University)

  • Ning Li

    (China Agricultural University)

  • Qingyong Meng

    (China Agricultural University
    China Agricultural University)

Abstract

Satellite cells are crucial for skeletal muscle regeneration, but the molecular mechanisms regulating satellite cells are not entirely understood. Here, we show that the immunoglobulin superfamily containing leucine-rich repeat (Islr), a newly identified marker for mesenchymal stem cells, stabilizes canonical Wnt signaling and promote skeletal muscle regeneration. Loss of Islr delays skeletal muscle regeneration in adult mice. In the absence of Islr, myoblasts fail to develop into mature myotubes due to defective differentiation. Islr interacts with Dishevelled-2 (Dvl2) to activate canonical Wnt signaling, consequently regulating the myogenic factor myogenin (MyoG). Furthermore, Islr stabilizes Dvl2 by reducing the level of LC3-labeled Dvl2 and preventing cells from undergoing autophagy. Together, our findings identify Islr as an important regulator for skeletal muscle regeneration.

Suggested Citation

  • Kuo Zhang & Yuying Zhang & Lijie Gu & Miaomiao Lan & Chuncheng Liu & Meng Wang & Yang Su & Mengxu Ge & Tongtong Wang & Yingying Yu & Chang Liu & Lei Li & Qiuyan Li & Yaofeng Zhao & Zhengquan Yu & Fudi, 2018. "Islr regulates canonical Wnt signaling-mediated skeletal muscle regeneration by stabilizing Dishevelled-2 and preventing autophagy," Nature Communications, Nature, vol. 9(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-07638-4
    DOI: 10.1038/s41467-018-07638-4
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