IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v9y2018i1d10.1038_s41467-018-07609-9.html
   My bibliography  Save this article

Real-time determination of enantiomeric and isomeric content using photoelectron elliptical dichroism

Author

Listed:
  • A. Comby

    (UMR5107)

  • E. Bloch

    (UMR5107)

  • C. M. M. Bond

    (Queen’s University)

  • D. Descamps

    (UMR5107)

  • J. Miles

    (Queen’s University)

  • S. Petit

    (UMR5107)

  • S. Rozen

    (Weizmann Institute of Science)

  • J. B. Greenwood

    (Queen’s University)

  • V. Blanchet

    (UMR5107)

  • Y. Mairesse

    (UMR5107)

Abstract

The fast and accurate analysis of chiral chemical mixtures is crucial for many applications but remains challenging. Here we use elliptically-polarized femtosecond laser pulses at high repetition rates to photoionize chiral molecules. The 3D photoelectron angular distribution produced provides molecular fingerprints, showing a strong forward-backward asymmetry which depends sensitively on the molecular structure and degree of ellipticity. Continuously scanning the laser ellipticity and analyzing the evolution of the rich, multi-dimensional molecular signatures allows us to observe real-time changes in the chemical and chiral content present with unprecedented speed and accuracy. We measure the enantiomeric excess of a compound with an accuracy of 0.4% in 10 min acquisition time, and follow the evolution of a mixture with an accuracy of 5% with a temporal resolution of 3 s. This method is even able to distinguish isomers, which cannot be easily distinguished by mass-spectrometry.

Suggested Citation

  • A. Comby & E. Bloch & C. M. M. Bond & D. Descamps & J. Miles & S. Petit & S. Rozen & J. B. Greenwood & V. Blanchet & Y. Mairesse, 2018. "Real-time determination of enantiomeric and isomeric content using photoelectron elliptical dichroism," Nature Communications, Nature, vol. 9(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-07609-9
    DOI: 10.1038/s41467-018-07609-9
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-018-07609-9
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-018-07609-9?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Etienne Rouquet & Madhusree Roy Chowdhury & Gustavo A. Garcia & Laurent Nahon & Jennifer Dupont & Valéria Lepère & Katia Le Barbu-Debus & Anne Zehnacker, 2023. "Induced photoelectron circular dichroism onto an achiral chromophore," Nature Communications, Nature, vol. 14(1), pages 1-8, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-07609-9. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.