IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v9y2018i1d10.1038_s41467-018-07584-1.html
   My bibliography  Save this article

Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias

Author

Listed:
  • Shahzya Chaudhury

    (University of Glasgow
    Royal Hospital for Children)

  • Caitríona O’Connor

    (University of Glasgow)

  • Ana Cañete

    (University of Glasgow)

  • Joana Bittencourt-Silvestre

    (University of Glasgow)

  • Evgenia Sarrou

    (University of Glasgow)

  • Áine Prendergast

    (University of Glasgow)

  • Jarny Choi

    (The University of Melbourne)

  • Pamela Johnston

    (University of Glasgow)

  • Christine A. Wells

    (The University of Melbourne)

  • Brenda Gibson

    (Royal Hospital for Children)

  • Karen Keeshan

    (University of Glasgow)

Abstract

Acute myeloid leukaemia (AML) affects children and adults of all ages. AML remains one of the major causes of death in children with cancer and for children with AML relapse is the most common cause of death. Here, by modelling AML in vivo we demonstrate that AML is discriminated by the age of the cell of origin. Young cells give rise to myeloid, lymphoid or mixed phenotype acute leukaemia, whereas adult cells give rise exclusively to AML, with a shorter latency. Unlike adult, young AML cells do not remodel the bone marrow stroma. Transcriptional analysis distinguishes young AML by the upregulation of immune pathways. Analysis of human paediatric AML samples recapitulates a paediatric immune cell interaction gene signature, highlighting two genes, RGS10 and FAM26F as prognostically significant. This work advances our understanding of paediatric AML biology, and provides murine models that offer the potential for developing paediatric specific therapeutic strategies.

Suggested Citation

  • Shahzya Chaudhury & Caitríona O’Connor & Ana Cañete & Joana Bittencourt-Silvestre & Evgenia Sarrou & Áine Prendergast & Jarny Choi & Pamela Johnston & Christine A. Wells & Brenda Gibson & Karen Keesha, 2018. "Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias," Nature Communications, Nature, vol. 9(1), pages 1-14, December.
  • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-07584-1
    DOI: 10.1038/s41467-018-07584-1
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-018-07584-1
    File Function: Abstract
    Download Restriction: no

    File URL: https://libkey.io/10.1038/s41467-018-07584-1?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Hope Mumme & Beena E. Thomas & Swati S. Bhasin & Upaasana Krishnan & Bhakti Dwivedi & Pruthvi Perumalla & Debasree Sarkar & Gulay B. Ulukaya & Himalee S. Sabnis & Sunita I. Park & Deborah DeRyckere & , 2023. "Single-cell analysis reveals altered tumor microenvironments of relapse- and remission-associated pediatric acute myeloid leukemia," Nature Communications, Nature, vol. 14(1), pages 1-20, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-07584-1. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.