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Nanoribbons self-assembled from short peptides demonstrate the formation of polar zippers between β-sheets

Author

Listed:
  • Meng Wang

    (China University of Petroleum (East China))

  • Jiqian Wang

    (China University of Petroleum (East China))

  • Peng Zhou

    (China University of Petroleum (East China))

  • Jing Deng

    (Chinese Academy of Sciences)

  • Yurong Zhao

    (China University of Petroleum (East China))

  • Yawei Sun

    (China University of Petroleum (East China))

  • Wei Yang

    (China University of Petroleum (East China))

  • Dong Wang

    (China University of Petroleum (East China))

  • Zongyi Li

    (The University of Manchester)

  • Xuzhi Hu

    (The University of Manchester)

  • Stephen M. King

    (STFC Rutherford Appleton Laboratory)

  • Sarah E. Rogers

    (STFC Rutherford Appleton Laboratory)

  • Henry Cox

    (The University of Manchester)

  • Thomas A. Waigh

    (The University of Manchester)

  • Jun Yang

    (Chinese Academy of Sciences)

  • Jian Ren Lu

    (The University of Manchester)

  • Hai Xu

    (China University of Petroleum (East China))

Abstract

Peptide self-assembly is a hierarchical process, often starting with the formation of α-helices, β-sheets or β-hairpins. However, how the secondary structures undergo further assembly to form higher-order architectures remains largely unexplored. The polar zipper originally proposed by Perutz is formed between neighboring β-strands of poly-glutamine via their side-chain hydrogen bonding and helps to stabilize the sheet. By rational design of short amphiphilic peptides and their self-assembly, here we demonstrate the formation of polar zippers between neighboring β-sheets rather than between β-strands within a sheet, which in turn intermesh the β-sheets into wide and flat ribbons. Such a super-secondary structural template based on well-defined hydrogen bonds could offer an agile route for the construction of distinctive nanostructures and nanomaterials beyond β-sheets.

Suggested Citation

  • Meng Wang & Jiqian Wang & Peng Zhou & Jing Deng & Yurong Zhao & Yawei Sun & Wei Yang & Dong Wang & Zongyi Li & Xuzhi Hu & Stephen M. King & Sarah E. Rogers & Henry Cox & Thomas A. Waigh & Jun Yang & J, 2018. "Nanoribbons self-assembled from short peptides demonstrate the formation of polar zippers between β-sheets," Nature Communications, Nature, vol. 9(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-07583-2
    DOI: 10.1038/s41467-018-07583-2
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