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Genomic analysis identifies frequent deletions of Dystrophin in olfactory neuroblastoma

Author

Listed:
  • Gary L. Gallia

    (Johns Hopkins University School of Medicine
    Johns Hopkins University School of Medicine
    Johns Hopkins University School of Medicine)

  • Ming Zhang

    (Johns Hopkins University School of Medicine)

  • Yi Ning

    (Johns Hopkins University School of Medicine)

  • Michael C. Haffner

    (Johns Hopkins University School of Medicine)

  • Denise Batista

    (Johns Hopkins University School of Medicine)

  • Zev A. Binder

    (Johns Hopkins University School of Medicine
    University of Pennsylvania)

  • Justin A. Bishop

    (Johns Hopkins University School of Medicine
    University of Texas Southwestern Medical Center)

  • Christine L. Hann

    (Johns Hopkins University School of Medicine)

  • Ralph H. Hruban

    (Johns Hopkins University School of Medicine)

  • Masaru Ishii

    (Johns Hopkins University School of Medicine
    Johns Hopkins University School of Medicine)

  • Alison P. Klein

    (Johns Hopkins University School of Medicine
    Johns Hopkins University School of Medicine)

  • Douglas D. Reh

    (Johns Hopkins University School of Medicine
    Johns Hopkins University School of Medicine)

  • Lisa M. Rooper

    (Johns Hopkins University School of Medicine)

  • Vafi Salmasi

    (Johns Hopkins University School of Medicine
    Stanford University School of Medicine)

  • Rafael J. Tamargo

    (Johns Hopkins University School of Medicine
    Johns Hopkins University School of Medicine)

  • Qing Wang

    (Johns Hopkins University School of Medicine)

  • Tara Williamson

    (Johns Hopkins University School of Medicine)

  • Tianna Zhao

    (Johns Hopkins University School of Medicine)

  • Ying Zou

    (University of Maryland School of Medicine)

  • Alan K. Meeker

    (Johns Hopkins University School of Medicine)

  • Nishant Agrawal

    (Johns Hopkins University School of Medicine
    University of Chicago)

  • Bert Vogelstein

    (Johns Hopkins University School of Medicine
    Johns Hopkins University School of Medicine)

  • Kenneth W. Kinzler

    (Johns Hopkins University School of Medicine)

  • Nickolas Papadopoulos

    (Johns Hopkins University School of Medicine)

  • Chetan Bettegowda

    (Johns Hopkins University School of Medicine
    Johns Hopkins University School of Medicine
    Johns Hopkins University School of Medicine
    Johns Hopkins University School of Medicine)

Abstract

Olfactory neuroblastoma (ONB) is a rare malignant neoplasm arising in the upper portion of the sinonasal cavity. To better understand the genetic bases for ONB, here we perform whole exome and whole genome sequencing as well as single nucleotide polymorphism array analyses in a series of ONB patient samples. Deletions involving the dystrophin (DMD) locus are found in 12 of 14 (86%) tumors. Interestingly, one of the remaining tumors has a deletion in LAMA2, bringing the number of ONBs with deletions of genes involved in the development of muscular dystrophies to 13 or 93%. This high prevalence implicates an unexpected functional role for genes causing hereditary muscular dystrophies in ONB.

Suggested Citation

  • Gary L. Gallia & Ming Zhang & Yi Ning & Michael C. Haffner & Denise Batista & Zev A. Binder & Justin A. Bishop & Christine L. Hann & Ralph H. Hruban & Masaru Ishii & Alison P. Klein & Douglas D. Reh &, 2018. "Genomic analysis identifies frequent deletions of Dystrophin in olfactory neuroblastoma," Nature Communications, Nature, vol. 9(1), pages 1-6, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-07578-z
    DOI: 10.1038/s41467-018-07578-z
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