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Studies into the mechanism of measles-associated immune suppression during a measles outbreak in the Netherlands

Author

Listed:
  • Brigitta M. Laksono

    (Postgraduate School of Molecular Medicine, Erasmus MC, University Medical Centre Rotterdam)

  • Rory D. de Vries

    (Postgraduate School of Molecular Medicine, Erasmus MC, University Medical Centre Rotterdam)

  • R. Joyce Verburgh

    (Postgraduate School of Molecular Medicine, Erasmus MC, University Medical Centre Rotterdam)

  • Eline G. Visser

    (Postgraduate School of Molecular Medicine, Erasmus MC, University Medical Centre Rotterdam)

  • Alwin de Jong

    (Postgraduate School of Molecular Medicine, Erasmus MC, University Medical Centre Rotterdam)

  • Pieter L. A. Fraaij

    (Postgraduate School of Molecular Medicine, Erasmus MC, University Medical Centre Rotterdam
    Postgraduate School of Molecular Medicine, Erasmus MC, University Medical Centre Rotterdam)

  • Wilhemina L. M. Ruijs

    (National Institute for Public Health and the Environment (RIVM))

  • David F. Nieuwenhuijse

    (Postgraduate School of Molecular Medicine, Erasmus MC, University Medical Centre Rotterdam)

  • Henk-Jan van den Ham

    (Postgraduate School of Molecular Medicine, Erasmus MC, University Medical Centre Rotterdam
    ENPICOM BV)

  • Marion P. G. Koopmans

    (Postgraduate School of Molecular Medicine, Erasmus MC, University Medical Centre Rotterdam)

  • Menno C. van Zelm

    (Postgraduate School of Molecular Medicine, Erasmus MC, University Medical Centre Rotterdam
    Monash University, and The Alfred Hospital)

  • Albert D. M. E. Osterhaus

    (Postgraduate School of Molecular Medicine, Erasmus MC, University Medical Centre Rotterdam
    University of Veterinary Medicine (TiHo-RIZ))

  • Rik L. de Swart

    (Postgraduate School of Molecular Medicine, Erasmus MC, University Medical Centre Rotterdam)

Abstract

Measles causes a transient immune suppression, leading to increased susceptibility to opportunistic infections. In experimentally infected non-human primates (NHPs) measles virus (MV) infects and depletes pre-existing memory lymphocytes, causing immune amnesia. A measles outbreak in the Dutch Orthodox Protestant community provided a unique opportunity to study the pathogenesis of measles immune suppression in unvaccinated children. In peripheral blood mononuclear cells (PBMC) of prodromal measles patients, we detected MV-infected memory CD4+ and CD8+ T cells and naive and memory B cells at similar levels as those observed in NHPs. In paired PBMC collected before and after measles we found reduced frequencies of circulating memory B cells and increased frequencies of regulatory T cells and transitional B cells after measles. These data support our immune amnesia hypothesis and offer an explanation for the previously observed long-term effects of measles on host resistance. This study emphasises the importance of maintaining high measles vaccination coverage.

Suggested Citation

  • Brigitta M. Laksono & Rory D. de Vries & R. Joyce Verburgh & Eline G. Visser & Alwin de Jong & Pieter L. A. Fraaij & Wilhemina L. M. Ruijs & David F. Nieuwenhuijse & Henk-Jan van den Ham & Marion P. G, 2018. "Studies into the mechanism of measles-associated immune suppression during a measles outbreak in the Netherlands," Nature Communications, Nature, vol. 9(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-07515-0
    DOI: 10.1038/s41467-018-07515-0
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    Cited by:

    1. Thomas Liechti & Yaser Iftikhar & Massimo Mangino & Margaret Beddall & Charles W. Goss & Jane A. O’Halloran & Philip A. Mudd & Mario Roederer, 2022. "Immune phenotypes that are associated with subsequent COVID-19 severity inferred from post-recovery samples," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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