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Memory formation and long-term maintenance of IL-7Rα+ ILC1s via a lymph node-liver axis

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  • Xianwei Wang

    (University of Science and Technology of China
    University of Science and Technology of China)

  • Hui Peng

    (University of Science and Technology of China
    University of Science and Technology of China)

  • Jingjing Cong

    (University of Science and Technology of China
    University of Science and Technology of China)

  • Xuefu Wang

    (University of Science and Technology of China
    University of Science and Technology of China)

  • Zhexiong Lian

    (University of Science and Technology of China
    University of Science and Technology of China)

  • Haiming Wei

    (University of Science and Technology of China
    University of Science and Technology of China)

  • Rui Sun

    (University of Science and Technology of China
    University of Science and Technology of China)

  • Zhigang Tian

    (University of Science and Technology of China
    University of Science and Technology of China)

Abstract

Natural killer (NK) cells are reported to have immunological memory, with CD49a+ liver-resident NK cells shown to confer hapten-specific memory responses, but how this memory is induced or maintained is unclear. Here we show that memory type I innate lymphoid cells (ILC1s), which express IL-7Rα, are generated in the lymph nodes (LNs) and require IL-7R signaling to maintain their longevity in the liver. Hapten sensitization initiates CXCR3-dependent recruitment of IL-7Rα+ ILC1s into skin-draining LNs, where they are primed and acquire hapten-specific memory potential. Memory IL-7Rα+ ILC1s then exit draining LNs and are preferentially recruited, via CXCR6, to reside in the liver. Moreover, long-term blockade of IL-7R signaling significantly reduces ILC1-mediated memory responses. Thus, our results identify a memory IL-7Rα+ ILC1 population and reveal a LN-liver axis that is essential for ILC1 memory generation and long-term maintenance.

Suggested Citation

  • Xianwei Wang & Hui Peng & Jingjing Cong & Xuefu Wang & Zhexiong Lian & Haiming Wei & Rui Sun & Zhigang Tian, 2018. "Memory formation and long-term maintenance of IL-7Rα+ ILC1s via a lymph node-liver axis," Nature Communications, Nature, vol. 9(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-07405-5
    DOI: 10.1038/s41467-018-07405-5
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    Cited by:

    1. Rui Ma & Zhenlong Li & Hejun Tang & Xiaojin Wu & Lei Tian & Zahir Shah & Ningyuan Liu & Tasha Barr & Jianying Zhang & Sean Wang & Srividya Swaminathan & Guido Marcucci & Yong Peng & Michael A. Caligiu, 2025. "NKp46 enhances type 1 innate lymphoid cell proliferation and function and anti-acute myeloid leukemia activity," Nature Communications, Nature, vol. 16(1), pages 1-16, December.

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