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The essential genome of the crenarchaeal model Sulfolobus islandicus

Author

Listed:
  • Changyi Zhang

    (University of Illinois at Urbana-Champaign
    University of Illinois at Urbana-Champaign)

  • Alex P. R. Phillips

    (University of Illinois at Urbana-Champaign
    University of Illinois at Urbana-Champaign)

  • Rebecca L. Wipfler

    (University of Illinois at Urbana-Champaign)

  • Gary J. Olsen

    (University of Illinois at Urbana-Champaign
    University of Illinois at Urbana-Champaign)

  • Rachel J. Whitaker

    (University of Illinois at Urbana-Champaign
    University of Illinois at Urbana-Champaign)

Abstract

Sulfolobus islandicus is a model microorganism in the TACK superphylum of the Archaea, a key lineage in the evolutionary history of cells. Here we report a genome-wide identification of the repertoire of genes essential to S. islandicus growth in culture. We confirm previous targeted gene knockouts, uncover the non-essentiality of functions assumed to be essential to the Sulfolobus cell, including the proteinaceous S-layer, and highlight essential genes whose functions are yet to be determined. Phyletic distributions illustrate the potential transitions that may have occurred during the evolution of this archaeal microorganism, and highlight sets of genes that may have been associated with each transition. We use this comparative context as a lens to focus future research on archaea-specific uncharacterized essential genes that may provide valuable insights into the evolutionary history of cells.

Suggested Citation

  • Changyi Zhang & Alex P. R. Phillips & Rebecca L. Wipfler & Gary J. Olsen & Rachel J. Whitaker, 2018. "The essential genome of the crenarchaeal model Sulfolobus islandicus," Nature Communications, Nature, vol. 9(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-07379-4
    DOI: 10.1038/s41467-018-07379-4
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    Cited by:

    1. Marie-Claire Daugeron & Sophia Missoury & Violette Cunha & Noureddine Lazar & Bruno Collinet & Herman Tilbeurgh & Tamara Basta, 2023. "A paralog of Pcc1 is the fifth core subunit of the KEOPS tRNA-modifying complex in Archaea," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Yuvaraj Bhoobalan-Chitty & Shuanshuan Xu & Laura Martinez-Alvarez & Svetlana Karamycheva & Kira S. Makarova & Eugene V. Koonin & Xu Peng, 2024. "Regulatory sequence-based discovery of anti-defense genes in archaeal viruses," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    3. Fabian Blombach & Michal Sýkora & Jo Case & Xu Feng & Diana P. Baquero & Thomas Fouqueau & Duy Khanh Phung & Declan Barker & Mart Krupovic & Qunxin She & Finn Werner, 2024. "Cbp1 and Cren7 form chromatin-like structures that ensure efficient transcription of long CRISPR arrays," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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