IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v9y2018i1d10.1038_s41467-018-07250-6.html
   My bibliography  Save this article

MR imaging tracking of inflammation-activatable engineered neutrophils for targeted therapy of surgically treated glioma

Author

Listed:
  • Meiying Wu

    (Chinese Academy of Sciences)

  • Haixian Zhang

    (Chinese Academy of Sciences
    Fudan University Shanghai Cancer Center)

  • Changjun Tie

    (Chinese Academy of Sciences
    Shenzhen Hospital of Guangzhou University of Chinese Medicine)

  • Chunhong Yan

    (Chinese Academy of Sciences)

  • Zhiting Deng

    (Chinese Academy of Sciences)

  • Qian Wan

    (Chinese Academy of Sciences)

  • Xin Liu

    (Chinese Academy of Sciences)

  • Fei Yan

    (Chinese Academy of Sciences)

  • Hairong Zheng

    (Chinese Academy of Sciences)

Abstract

Cell-based drug delivery systems have shown promising capability for tumor-targeted therapy owing to the intrinsic tumor-homing and drug-carrying property of some living cells. However, imaging tracking of their migration and bio-effects is urgently needed for clinical application, especially for glioma. Here, we report the inflammation-activatable engineered neutrophils by internalizing doxorubicin-loaded magnetic mesoporous silica nanoparticles (ND-MMSNs) which can provide the potential for magnetic resonance (MR) imaging tracking of the drug-loaded cells to actively target inflamed brain tumor after surgical resection of primary tumor. The phagocytized D-MMSNs possess high drug loading efficiency and do not affect the host neutrophils’ viability, thus remarkably improving intratumoral drug concentration and delaying relapse of surgically treated glioma. Our study offers a new strategy in targeted cancer theranostics through combining the merits of living cells and nanoparticle carriers.

Suggested Citation

  • Meiying Wu & Haixian Zhang & Changjun Tie & Chunhong Yan & Zhiting Deng & Qian Wan & Xin Liu & Fei Yan & Hairong Zheng, 2018. "MR imaging tracking of inflammation-activatable engineered neutrophils for targeted therapy of surgically treated glioma," Nature Communications, Nature, vol. 9(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-07250-6
    DOI: 10.1038/s41467-018-07250-6
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-018-07250-6
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-018-07250-6?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-07250-6. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.