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Adaptation to sub-optimal hosts is a driver of viral diversification in the ocean

Author

Listed:
  • Hagay Enav

    (Technion-Israel Institute of Technology
    Max-Planck Institute for Developmental Biology)

  • Shay Kirzner

    (Technion-Israel Institute of Technology)

  • Debbie Lindell

    (Technion-Israel Institute of Technology)

  • Yael Mandel-Gutfreund

    (Technion-Israel Institute of Technology
    Technion-Israel Institute of Technology)

  • Oded Béjà

    (Technion-Israel Institute of Technology)

Abstract

Cyanophages of the Myoviridae family include generalist viruses capable of infecting a wide range of hosts including those from different cyanobacterial genera. While the influence of phages on host evolution has been studied previously, it is not known how the infection of distinct hosts influences the evolution of cyanophage populations. Here, using an experimental evolution approach, we investigated the adaptation of multiple cyanophage populations to distinct cyanobacterial hosts. We show that when infecting an “optimal” host, whose infection is the most efficient, phage populations accumulated only a few mutations. However, when infecting “sub-optimal” hosts, different mutations spread in the phage populations, leading to rapid diversification into distinct subpopulations. Based on our results, we propose a model demonstrating how shifts in microbial abundance, which lead to infection of “sub-optimal” hosts, act as a driver for rapid diversification of viral populations.

Suggested Citation

  • Hagay Enav & Shay Kirzner & Debbie Lindell & Yael Mandel-Gutfreund & Oded Béjà, 2018. "Adaptation to sub-optimal hosts is a driver of viral diversification in the ocean," Nature Communications, Nature, vol. 9(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-07164-3
    DOI: 10.1038/s41467-018-07164-3
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