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Connectivity and network state-dependent recruitment of long-range VIP-GABAergic neurons in the mouse hippocampus

Author

Listed:
  • Ruggiero Francavilla

    (Université Laval
    Université Laval)

  • Vincent Villette

    (Université Laval
    Université Laval)

  • Xiao Luo

    (Université Laval
    Université Laval)

  • Simon Chamberland

    (Université Laval)

  • Einer Muñoz-Pino

    (Université Laval
    Université Laval)

  • Olivier Camiré

    (Université Laval
    Université Laval)

  • Kristina Wagner

    (Oxford University)

  • Viktor Kis

    (Oxford University)

  • Peter Somogyi

    (Oxford University)

  • Lisa Topolnik

    (Université Laval
    Université Laval)

Abstract

GABAergic interneurons in the hippocampus provide for local and long-distance coordination of neurons in functionally connected areas. Vasoactive intestinal peptide-expressing (VIP+) interneurons occupy a distinct niche in circuitry as many of them specialize in innervating GABAergic cells, thus providing network disinhibition. In the CA1 hippocampus, VIP+ interneuron-selective cells target local interneurons. Here, we discover a type of VIP+ neuron whose axon innervates CA1 and also projects to the subiculum (VIP-LRPs). VIP-LRPs show specific molecular properties and target interneurons within the CA1 area but both interneurons and pyramidal cells within subiculum. They are interconnected through gap junctions but demonstrate sparse spike coupling in vitro. In awake mice, VIP-LRPs decrease their activity during theta-run epochs and are more active during quiet wakefulness but not coupled to sharp-wave ripples. Together, the data provide evidence for VIP interneuron molecular diversity and functional specialization in controlling cell ensembles along the hippocampo-subicular axis.

Suggested Citation

  • Ruggiero Francavilla & Vincent Villette & Xiao Luo & Simon Chamberland & Einer Muñoz-Pino & Olivier Camiré & Kristina Wagner & Viktor Kis & Peter Somogyi & Lisa Topolnik, 2018. "Connectivity and network state-dependent recruitment of long-range VIP-GABAergic neurons in the mouse hippocampus," Nature Communications, Nature, vol. 9(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-07162-5
    DOI: 10.1038/s41467-018-07162-5
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