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Whole body PD-1 and PD-L1 positron emission tomography in patients with non-small-cell lung cancer

Author

Listed:
  • A. N. Niemeijer

    (Amsterdam UMC, Vrije Universiteit Amsterdam)

  • D. Leung

    (Bristol-Myers Squibb Research and Development)

  • M. C. Huisman

    (Amsterdam UMC, Vrije Universiteit Amsterdam)

  • I. Bahce

    (Amsterdam UMC, Vrije Universiteit Amsterdam)

  • O. S. Hoekstra

    (Amsterdam UMC, Vrije Universiteit Amsterdam)

  • G. A. M. S. Dongen

    (Amsterdam UMC, Vrije Universiteit Amsterdam)

  • R. Boellaard

    (Amsterdam UMC, Vrije Universiteit Amsterdam)

  • S. Du

    (Bristol-Myers Squibb Research and Development)

  • W. Hayes

    (Bristol-Myers Squibb Research and Development)

  • R. Smith

    (Bristol-Myers Squibb Research and Development)

  • A. D. Windhorst

    (Amsterdam UMC, Vrije Universiteit Amsterdam)

  • N. H. Hendrikse

    (Amsterdam UMC, Vrije Universiteit Amsterdam)

  • A. Poot

    (Amsterdam UMC, Vrije Universiteit Amsterdam)

  • D. J. Vugts

    (Amsterdam UMC, Vrije Universiteit Amsterdam)

  • E. Thunnissen

    (Amsterdam UMC, Vrije Universiteit Amsterdam)

  • P. Morin

    (Bristol-Myers Squibb Research and Development)

  • D. Lipovsek

    (Bristol-Myers Squibb Research and Development)

  • D. J. Donnelly

    (Bristol-Myers Squibb Research and Development)

  • S. J. Bonacorsi

    (Bristol-Myers Squibb Research and Development)

  • L. M. Velasquez

    (Bristol-Myers Squibb Research and Development)

  • T. D. Gruijl

    (Amsterdam UMC, Vrije Universiteit Amsterdam)

  • E. F. Smit

    (Netherlands Cancer Institute)

  • A. J. Langen

    (Amsterdam UMC, Vrije Universiteit Amsterdam
    Netherlands Cancer Institute)

Abstract

PD-L1 immunohistochemistry correlates only moderately with patient survival and response to PD-(L)1 treatment. Heterogeneity of tumor PD-L1 expression might limit the predictive value of small biopsies. Here we show that tumor PD-L1 and PD-1 expression can be quantified non-invasively using PET-CT in patients with non-small-cell lung cancer. Whole body PD-(L)1 PET-CT reveals significant tumor tracer uptake heterogeneity both between patients, as well as within patients between different tumor lesions.

Suggested Citation

  • A. N. Niemeijer & D. Leung & M. C. Huisman & I. Bahce & O. S. Hoekstra & G. A. M. S. Dongen & R. Boellaard & S. Du & W. Hayes & R. Smith & A. D. Windhorst & N. H. Hendrikse & A. Poot & D. J. Vugts & E, 2018. "Whole body PD-1 and PD-L1 positron emission tomography in patients with non-small-cell lung cancer," Nature Communications, Nature, vol. 9(1), pages 1-5, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-07131-y
    DOI: 10.1038/s41467-018-07131-y
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