IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v9y2018i1d10.1038_s41467-018-07120-1.html
   My bibliography  Save this article

Sex separation induces differences in the olfactory sensory receptor repertoires of male and female mice

Author

Listed:
  • Carl van der Linden

    (University of Wyoming)

  • Susanne Jakob

    (Harvard University
    Harvard University)

  • Pooja Gupta

    (University of Wyoming)

  • Catherine Dulac

    (Harvard University)

  • Stephen W. Santoro

    (University of Wyoming)

Abstract

Within the mammalian olfactory sensory epithelium, experience-dependent changes in the rate of neuronal turnover can alter the relative abundance of neurons expressing specific chemoreceptors. Here we investigate how the mouse olfactory sensory receptor repertoire changes as a function of exposure to odors emitted from members of the opposite sex, which are highly complex and sexually dimorphic. Upon housing mice either sex-separated or sex-combined until six months of age, we find that sex-separated mice exhibit significantly more numerous differentially expressed genes within their olfactory epithelia. A subset of these chemoreceptors exhibit altered expression frequencies following both sex-separation and olfactory deprivation. We show that several of these receptors detect either male- or female-specific odors. We conclude that the distinct odor experiences of sex-separated male and female mice induce sex-specific differences in the abundance of neurons that detect sexually dimorphic odors.

Suggested Citation

  • Carl van der Linden & Susanne Jakob & Pooja Gupta & Catherine Dulac & Stephen W. Santoro, 2018. "Sex separation induces differences in the olfactory sensory receptor repertoires of male and female mice," Nature Communications, Nature, vol. 9(1), pages 1-15, December.
  • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-07120-1
    DOI: 10.1038/s41467-018-07120-1
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-018-07120-1
    File Function: Abstract
    Download Restriction: no

    File URL: https://libkey.io/10.1038/s41467-018-07120-1?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Predrag Jovanovic & Allan-Hermann Pool & Nancy Morones & Yidan Wang & Edward Novinbakht & Nareg Keshishian & Kaitlyn Jang & Yuki Oka & Celine E. Riera, 2023. "A sex-specific thermogenic neurocircuit induced by predator smell recruiting cholecystokinin neurons in the dorsomedial hypothalamus," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    2. Benjamin Padilla-Morales & Alin P. Acuña-Alonzo & Huseyin Kilili & Atahualpa Castillo-Morales & Karina Díaz-Barba & Kathryn H. Maher & Laurie Fabian & Evangelos Mourkas & Tamás Székely & Martin-Alejan, 2024. "Sexual size dimorphism in mammals is associated with changes in the size of gene families related to brain development," Nature Communications, Nature, vol. 15(1), pages 1-11, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-07120-1. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.