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An oviduct-on-a-chip provides an enhanced in vitro environment for zygote genome reprogramming

Author

Listed:
  • Marcia A. M. M. Ferraz

    (Utrecht University
    Utrecht University)

  • Hoon Suk Rho

    (University of Twente)

  • Daiane Hemerich

    (University Medical Center Utrecht
    Ministry of Education of Brazil)

  • Heiko H. W. Henning

    (Utrecht University)

  • Helena T. A. Tol

    (Utrecht University)

  • Michael Hölker

    (University of Bonn
    University of Bonn)

  • Urban Besenfelder

    (University of Veterinary Medicine Vienna)

  • Michal Mokry

    (University Medical Center Utrecht)

  • Peter L. A. M. Vos

    (Utrecht University)

  • Tom A. E. Stout

    (Utrecht University)

  • Séverine Gac

    (University of Twente)

  • Bart M. Gadella

    (Utrecht University
    Utrecht University)

Abstract

Worldwide over 5 million children have been conceived using assisted reproductive technology, and research has concentrated on increasing the likelihood of ongoing pregnancy. However, studies using animal models have indicated undesirable effects of in vitro embryo culture on offspring development and health. In vivo, the oviduct hosts a period in which the early embryo undergoes complete reprogramming of its (epi)genome in preparation for the reacquisition of (epi)genetic marks. We designed an oviduct-on-a-chip platform to better investigate the mechanisms related to (epi)genetic reprogramming and the degree to which they differ between in vitro and in vivo embryos. The device supports more physiological (in vivo-like) zygote genetic reprogramming than conventional IVF. This approach will be instrumental in identifying and investigating factors critical to fertilization and pre-implantation development, which could improve the quality and (epi)genetic integrity of IVF zygotes with likely relevance for early embryonic and later fetal development.

Suggested Citation

  • Marcia A. M. M. Ferraz & Hoon Suk Rho & Daiane Hemerich & Heiko H. W. Henning & Helena T. A. Tol & Michael Hölker & Urban Besenfelder & Michal Mokry & Peter L. A. M. Vos & Tom A. E. Stout & Séverine G, 2018. "An oviduct-on-a-chip provides an enhanced in vitro environment for zygote genome reprogramming," Nature Communications, Nature, vol. 9(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-07119-8
    DOI: 10.1038/s41467-018-07119-8
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