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Self-implantable double-layered micro-drug-reservoirs for efficient and controlled ocular drug delivery

Author

Listed:
  • Aung Than

    (Nanyang Technological University)

  • Chenghao Liu

    (Nanyang Technological University)

  • Hao Chang

    (Nanyang Technological University)

  • Phan Khanh Duong

    (Nanyang Technological University)

  • Chui Ming Gemmy Cheung

    (Singapore National Eye Centre
    Singapore Eye Research Institute
    National University of Singapore)

  • Chenjie Xu

    (Nanyang Technological University)

  • Xiaomeng Wang

    (Nanyang Technological University
    Singapore National Eye Centre
    Agency for Science, Technology & Research
    University College London)

  • Peng Chen

    (Nanyang Technological University)

Abstract

Eye diseases and injuries impose a significant clinical problem worldwide. Safe and effective ocular drug delivery is, however, challenging due to the presence of ocular barriers. Here we report a strategy using an eye patch equipped with an array of detachable microneedles. These microneedles can penetrate the ocular surface tissue, and serve as implanted micro-reservoirs for controlled drug delivery. The biphasic drug release kinetics enabled by the double-layered micro-reservoirs largely enhances therapeutic efficacy. Using corneal neovascularization as the disease model, we show that delivery of an anti-angiogenic monoclonal antibody (DC101) by such eye patch produces ~90% reduction of neovascular area. Furthermore, quick release of an anti-inflammatory compound (diclofenac) followed by a sustained release of DC101 provides synergistic therapeutic outcome. The eye patch application is easy and minimally invasive to ensure good patient compliance. Such intraocular drug delivery strategy promises effective home-based treatment of many eye diseases.

Suggested Citation

  • Aung Than & Chenghao Liu & Hao Chang & Phan Khanh Duong & Chui Ming Gemmy Cheung & Chenjie Xu & Xiaomeng Wang & Peng Chen, 2018. "Self-implantable double-layered micro-drug-reservoirs for efficient and controlled ocular drug delivery," Nature Communications, Nature, vol. 9(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-06981-w
    DOI: 10.1038/s41467-018-06981-w
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