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Mycoplasma genitalium adhesin P110 binds sialic-acid human receptors

Author

Listed:
  • David Aparicio

    (Instituto de Biología Molecular de Barcelona (IBMB-CSIC) and Maria de Maeztu Unit of Excellence, Parc Científic de Barcelona)

  • Sergi Torres-Puig

    (Universitat Autònoma de Barcelona)

  • Mercè Ratera

    (Instituto de Biología Molecular de Barcelona (IBMB-CSIC) and Maria de Maeztu Unit of Excellence, Parc Científic de Barcelona)

  • Enrique Querol

    (Universitat Autònoma de Barcelona)

  • Jaume Piñol

    (Universitat Autònoma de Barcelona)

  • Oscar Q. Pich

    (Universitat Autònoma de Barcelona)

  • Ignacio Fita

    (Instituto de Biología Molecular de Barcelona (IBMB-CSIC) and Maria de Maeztu Unit of Excellence, Parc Científic de Barcelona)

Abstract

Adhesion of pathogenic bacteria to target cells is a prerequisite for colonization and further infection. The main adhesins of the emerging sexually transmitted pathogen Mycoplasma genitalium, P140 and P110, interact to form a Nap complex anchored to the cell membrane. Herein, we present the crystal structures of the extracellular region of the virulence factor P110 (916 residues) unliganded and in complex with sialic acid oligosaccharides. P110 interacts only with the neuraminic acid moiety of the oligosaccharides and experiments with human cells demonstrate that these interactions are essential for mycoplasma cytadherence. Additionally, structural information provides a deep insight of the P110 antigenic regions undergoing programmed variation to evade the host immune response. These results enlighten the interplay of M. genitalium with human target cells, offering new strategies to control mycoplasma infections.

Suggested Citation

  • David Aparicio & Sergi Torres-Puig & Mercè Ratera & Enrique Querol & Jaume Piñol & Oscar Q. Pich & Ignacio Fita, 2018. "Mycoplasma genitalium adhesin P110 binds sialic-acid human receptors," Nature Communications, Nature, vol. 9(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-06963-y
    DOI: 10.1038/s41467-018-06963-y
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