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Genome-wide associations for benign prostatic hyperplasia reveal a genetic correlation with serum levels of PSA

Author

Listed:
  • Julius Gudmundsson

    (deCODE genetics/AMGEN)

  • Jon K. Sigurdsson

    (deCODE genetics/AMGEN)

  • Lilja Stefansdottir

    (deCODE genetics/AMGEN)

  • Bjarni A. Agnarsson

    (Landspitali-University Hospital
    University of Iceland)

  • Helgi J. Isaksson

    (Landspitali-University Hospital)

  • Olafur A. Stefansson

    (deCODE genetics/AMGEN)

  • Sigurjon A. Gudjonsson

    (deCODE genetics/AMGEN)

  • Daniel F. Gudbjartsson

    (deCODE genetics/AMGEN
    University of Iceland)

  • Gisli Masson

    (deCODE genetics/AMGEN)

  • Michael L. Frigge

    (deCODE genetics/AMGEN)

  • Simon N. Stacey

    (deCODE genetics/AMGEN)

  • Patrick Sulem

    (deCODE genetics/AMGEN)

  • Gisli H. Halldorsson

    (deCODE genetics/AMGEN)

  • Vinicius Tragante

    (deCODE genetics/AMGEN
    University of Utrecht)

  • Hilma Holm

    (deCODE genetics/AMGEN)

  • Gudmundur I. Eyjolfsson

    (The Clinical Laboratory in Mjodd)

  • Olof Sigurdardottir

    (Akureyri Hospital)

  • Isleifur Olafsson

    (Landspitali-University Hospital)

  • Thorvaldur Jonsson

    (Landspitali-University Hospital
    University of Iceland)

  • Eirikur Jonsson

    (Landspitali-University Hospital
    University of Iceland)

  • Rosa B. Barkardottir

    (Landspitali University Hospital
    University of Iceland)

  • Rafn Hilmarsson

    (Landspitali-University Hospital)

  • Folkert W. Asselbergs

    (University of Utrecht
    Netherlands Heart Institute
    University College London
    University College London)

  • Gudmundur Geirsson

    (Landspitali-University Hospital
    University of Iceland)

  • Unnur Thorsteinsdottir

    (deCODE genetics/AMGEN
    University of Iceland)

  • Thorunn Rafnar

    (deCODE genetics/AMGEN)

  • Gudmar Thorleifsson

    (deCODE genetics/AMGEN)

  • Kari Stefansson

    (deCODE genetics/AMGEN
    University of Iceland)

Abstract

Benign prostatic hyperplasia and associated lower urinary tract symptoms (BPH/LUTS) are common conditions affecting the majority of elderly males. Here we report the results of a genome-wide association study of symptomatic BPH/LUTS in 20,621 patients and 280,541 controls of European ancestry, from Iceland and the UK. We discovered 23 genome-wide significant variants, located at 14 loci. There is little or no overlap between the BPH/LUTS variants and published prostate cancer risk variants. However, 15 of the variants reported here also associate with serum levels of prostate specific antigen (PSA) (at a Bonferroni corrected P

Suggested Citation

  • Julius Gudmundsson & Jon K. Sigurdsson & Lilja Stefansdottir & Bjarni A. Agnarsson & Helgi J. Isaksson & Olafur A. Stefansson & Sigurjon A. Gudjonsson & Daniel F. Gudbjartsson & Gisli Masson & Michael, 2018. "Genome-wide associations for benign prostatic hyperplasia reveal a genetic correlation with serum levels of PSA," Nature Communications, Nature, vol. 9(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-06920-9
    DOI: 10.1038/s41467-018-06920-9
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    Cited by:

    1. Renee E. Vickman & LaTayia Aaron-Brooks & Renyuan Zhang & Nadia A. Lanman & Brittany Lapin & Victoria Gil & Max Greenberg & Takeshi Sasaki & Gregory M. Cresswell & Meaghan M. Broman & J. Sebastian Pae, 2022. "TNF is a potential therapeutic target to suppress prostatic inflammation and hyperplasia in autoimmune disease," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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